A1 Refereed original research article in a scientific journal
Maternal Vitamin C and Iron Intake during Pregnancy and the Risk of Islet Autoimmunity and Type 1 Diabetes in Children: A Birth Cohort Study
Authors: Mattila Markus, Hakola Leena, Niinistö Sari, Tapanainen Heli, Takkinen Hanna-Mari, Ahonen Suvi, Ilonen Jorma, Toppari Jorma, Veijola Riitta, Knip Mikael, Virtanen Suvi M
Publisher: MDPI
Publication year: 2021
Journal: Nutrients
Journal name in source: NUTRIENTS
Journal acronym: NUTRIENTS
Article number: ARTN 928
Volume: 13
Issue: 3
Number of pages: 11
eISSN: 2072-6643
DOI: https://doi.org/10.3390/nu13030928
Self-archived copy’s web address: https://research.utu.fi/converis/portal/detail/Publication/55076500
Our aim was to study the associations between maternal vitamin C and iron intake during pregnancy and the offspring's risk of developing islet autoimmunity and type 1 diabetes. The study was a part of the Finnish Type 1 Diabetes Prediction and Prevention (DIPP) prospective birth cohort including children genetically at risk of type 1 diabetes born between 1997-2004. The diets of 4879 mothers in late pregnancy were assessed with a validated food frequency questionnaire. The outcomes were islet autoimmunity and type 1 diabetes. Cox proportional hazards regression analysis adjusted for energy, family history of diabetes, human leukocyte antigen (HLA) genotype and sex was used for statistical analyses. Total intake of vitamin C or iron from food and supplements was not associated with the risk of islet autoimmunity (vitamin C: HR 0.91: 95% CI (0.80, 1.03), iron: 0.98 (0.87, 1.10)) or type 1 diabetes (vitamin C: 1.01 (0.87, 1.17), iron: 0.92 (0.78, 1.08)), neither was the use of vitamin C or iron supplements associated with the outcomes. In conclusion, no association was found between maternal vitamin C or iron intake during pregnancy and the risk of islet autoimmunity or type 1 diabetes in the offspring.
Downloadable publication This is an electronic reprint of the original article. |  |
