A1 Refereed original research article in a scientific journal
Serum cytokine profile of pediatric patients with laboratory confirmed pneumococcal meningitis
Authors: Zheng Kai, Zhu Liang, Ding Yiwei, Zhang Xixi, Chen Ning, Liu Gang, He Qiushui
Publisher: ELSEVIER SCIENCE LONDON
Publication year: 2021
Journal: Journal of Infection and Public Health
Journal name in source: JOURNAL OF INFECTION AND PUBLIC HEALTH
Journal acronym: J INFECT PUBLIC HEAL
Volume: 14
Issue: 4
First page : 514
Last page: 520
Number of pages: 7
ISSN: 1876-0341
eISSN: 1876-035X
DOI: https://doi.org/10.1016/j.jiph.2021.01.010
Web address : https://www.sciencedirect.com/science/article/pii/S1876034121000150
Self-archived copy’s web address: https://research.utu.fi/converis/portal/detail/Publication/54598989
Background: Streptococcus pneumoniae infection is a leading cause of bacterial meningitis in children with severe sequelae. Cytokines are important molecules in regulating of host inflammatory and antiinflammatory responses. So far, the cytokine profile of bacterial meningitis caused by single pathogen has been rarely reported. The aim of this study was to explore serum cytokine profile in pediatric patients with pneumococcal meningitis (PM) and its clinical relevance which could be considered as a valuable tool for differential diagnosis of PM.
Methods: During 2015 & ndash;2018, 95 children with laboratory-confirmed PM were included. Of them, 63 had serum samples at admission. Ten cytokines including TNF-a, IL-12p40, IL-17A, IL-1(3, IFN-eta, GM-CSF, IL-10, CXCL-1, IL-8 and IL-13 were measured by multiplex immunoassay in sera of 63 PM patients and 55 age-matched healthy controls (HCs). Level of serum cytokines was compared with different clinical features of patients.
Results: Significantly higher level of IL-10 was observed in patients than HCs (median, 2.19 vs. 1.92 pg/mL, p = 0.017). Significantly lower levels of serum IL-12p40, IL-17A and IL-1 beta were observed in patients than HCs (median, 0.68 vs. 10.12 pg/mL, p < 0.0001; 1.14 vs. 1.14 pg/mL, p = 0.004; 1.00 vs. 5.09 pg/mL, p < 0.0001, respectively). No difference was found in levels of other cytokines between patients and controls. A negative correlation was noticed between percentages of blood neutrophils and concentrations of IL-10 (p = 0.048, r = & minus;0.25). Significantly lower levels of IL-12p40 and CXCL-1 were observed in PM patients with sepsis than those without (median 0.68 vs. 1.64 pg/mL, p = 0.026; 7.25 vs. 12.84 pg/mL, p = 0.043, respectively).
Conclusions: Our results suggested that there might be significant changes in serum pro-inflammatory and anti-inflammatory cytokines in PM children and that the determination of these cytokines may have limited value for evaluation of clinical outcome of pediatric PM.
(c) 2021 The Author(s). Published by Elsevier Ltd on behalf of King Saud Bin Abdulaziz University for Health Sciences. This is an open access article under the CC BY-NC-ND license (http://creativecommons. org/licenses/by-nc-nd/4.0/).
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