A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Childhood asthma outcomes during the COVID-19 pandemic: Findings from the PeARL multinational cohort
Tekijät: Papadopoulos Nikolaos G, Mathioudakis Alexander G, Custovic Adnan, Deschildre Antoine, Phipatanakul Wanda, Wong Gary, Xepapadaki Paraskevi, Abou-Taam Rola, Agache Ioana, Castro-Rodriguez Jose A, Chen Zhimin, Cros Pierrick, Dubus Jean-Christophe, El-Sayed Zeinab Awad, El-Owaidy Rasha, Feleszko Wojciech, Fierro Vincenzo, Fiocchi Alessandro, Garcia-Marcos Luis, Goh Anne, Hossny Elham M, Villalobos Yunuen R Huerta, Jartti Tuomas, Le Roux Pascal, Levina Julia, Garcia Aida Inés López, Ramos Ángel Mazón, Morais-Almeida Mário, Murray Clare, Nagaraju Karthik, Nagaraju Major K, Rodriguez Elsy Maureen Navarrete, Namazova-Baranova Leyla, Garcia Antonio Nieto, Beltran Cesar Fireth Pozo, Ratchataswan Thanaporn, Yeverino Daniela Rivero, Zagal Eréndira Rodríguez, Schweitzer Cyril E, Tulkki Marleena, Wasilczuk Katarzyna, Xu Dan; PeARL collaborators; on behalf of the PeARL Think Tank
Kustantaja: WILEY
Julkaisuvuosi: 2021
Journal: Allergy
Tietokannassa oleva lehden nimi: ALLERGY
Lehden akronyymi: ALLERGY
Vuosikerta: 76
Numero: 6
Aloitussivu: 1765
Lopetussivu: 1775
Sivujen määrä: 11
ISSN: 0105-4538
eISSN: 1398-9995
DOI: https://doi.org/10.1111/all.14787
Verkko-osoite: https://onlinelibrary.wiley.com/doi/10.1111/all.14787
Rinnakkaistallenteen osoite: https://research.utu.fi/converis/portal/detail/Publication/53990560
Background
The interplay between COVID-19 pandemic and asthma in children is still unclear. We evaluated the impact of COVID-19 pandemic on childhood asthma outcomes.
Methods
The PeARL multinational cohort included 1,054 children with asthma and 505 non-asthmatic children aged between 4 and 18 years from 25 pediatric departments, from 15 countries globally. We compared the frequency of acute respiratory and febrile presentations during the first wave of the COVID-19 pandemic between groups and with data available from the previous year. In children with asthma, we also compared current and historical disease control.
Results
During the pandemic, children with asthma experienced fewer upper respiratory tract infections, episodes of pyrexia, emergency visits, hospital admissions, asthma attacks, and hospitalizations due to asthma, in comparison with the preceding year. Sixty-six percent of asthmatic children had improved asthma control while in 33% the improvement exceeded the minimal clinically important difference. Pre-bronchodilatation FEV1 and peak expiratory flow rate were improved during the pandemic. When compared to non-asthmatic controls, children with asthma were not at increased risk of LRTIs, episodes of pyrexia, emergency visits, or hospitalizations during the pandemic. However, an increased risk of URTIs emerged.
Conclusion
Childhood asthma outcomes, including control, were improved during the first wave of the COVID-19 pandemic, probably because of reduced exposure to asthma triggers and increased treatment adherence. The decreased frequency of acute episodes does not support the notion that childhood asthma may be a risk factor for COVID-19. Furthermore, the potential for improving childhood asthma outcomes through environmental control becomes apparent.
Ladattava julkaisu This is an electronic reprint of the original article. |  |
