Vertaisarvioitu katsausartikkeli tieteellisessä aikakauslehdessä (A2)

Nicotine Replacement Therapy during Pregnancy and Child Health Outcomes: A Systematic Review




Julkaisun tekijätBlanc Julie, Tosello Barthélémy, Ekblad Mikael O., Berlin Ivan, Netter Antoine

KustantajaMDPI

Julkaisuvuosi2021

JournalInternational Journal of Environmental Research and Public Health

Volyymi18

Julkaisunumero8

eISSN1660-4601

DOIhttp://dx.doi.org/10.3390/ijerph18084004

Verkko-osoitehttps://doi.org/10.3390/ijerph18084004

Rinnakkaistallenteen osoitehttps://research.utu.fi/converis/portal/detail/Publication/53425628


Tiivistelmä

Tobacco smoking in pregnancy is a worldwide public health problem. A majority of pregnant smokers need assistance to stop smoking. Most scientific societies recommend nicotine re- placement therapy (NRT) during pregnancy but this recommendation remains controversial because of the known fetal toxicity of nicotine. The objective of this systematic review was to provide an overview of human studies about child health outcomes associated with NRT use during pregnancy. The electronic databases MEDLINE, the Cochrane Database, Web of Science, and ClinicalTrials.gov were searched from the inception of each database until 26 December 2020. A total of 103 articles were identified through database searching using combination of keywords. Out of 75 screened articles and after removal of duplicates, ten full-text articles were assessed for eligibility and five were included in the qualitative synthesis. NRT prescription seems to be associated with higher risk of infantile colic at 6 months as in case of smoking during pregnancy, and with risk of attention- deficit/hyperactivity disorder. No association between NRT during pregnancy and other infant health disorders or major congenital anomalies has been reported. Well-designed controlled clinical trials with sufficient follows-up are needed to provide more information on the use of NRT or other pharmacotherapies for smoking cessation during pregnancy on post-natal child health outcomes.


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Last updated on 2022-19-12 at 15:52