A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Indirect Selection against Antibiotic Resistance via Specialized Plasmid-Dependent Bacteriophages
Tekijät: Penttinen Reetta, Given Cindy, Jalasvuori Matti
Kustantaja: MDPI
Julkaisuvuosi: 2021
Journal: Microorganisms
Tietokannassa oleva lehden nimi: MICROORGANISMS
Lehden akronyymi: MICROORGANISMS
Artikkelin numero: ARTN 280
Vuosikerta: 9
Numero: 2
Sivujen määrä: 11
eISSN: 2076-2607
DOI: https://doi.org/10.3390/microorganisms9020280
Rinnakkaistallenteen osoite: https://research.utu.fi/converis/portal/detail/Publication/53419288
Antibiotic resistance genes of important Gram-negative bacterial pathogens are residing in mobile genetic elements such as conjugative plasmids. These elements rapidly disperse between cells when antibiotics are present and hence our continuous use of antimicrobials selects for elements that often harbor multiple resistance genes. Plasmid-dependent (or male-specific or, in some cases, pilus-dependent) bacteriophages are bacterial viruses that infect specifically bacteria that carry certain plasmids. The introduction of these specialized phages into a plasmid-abundant bacterial community has many beneficial effects from an anthropocentric viewpoint: the majority of the plasmids are lost while the remaining plasmids acquire mutations that make them untransferable between pathogens. Recently, bacteriophage-based therapies have become a more acceptable choice to treat multi-resistant bacterial infections. Accordingly, there is a possibility to utilize these specialized phages, which are not dependent on any particular pathogenic species or strain but rather on the resistance-providing elements, in order to improve or enlengthen the lifespan of conventional antibiotic approaches. Here, we take a snapshot of the current knowledge of plasmid-dependent bacteriophages.
Ladattava julkaisu This is an electronic reprint of the original article. |  |
