Synthesis of fully protected trinucleotide building blocks on a disulphide-linked soluble support

: Suchsland Ruth, Appel Bettina, Virta Pasi, Müller Sabine

Publisher: ROYAL SOC CHEMISTRY

: 2021

: RSC Advances

: RSC ADVANCES

: RSC ADV

: 11

: 7

: 3892

: 3896

: 5

: 2046-2069

DOI: https://doi.org/10.1039/d0ra10941j

: https://pubs.rsc.org/en/content/articlelanding/2021/RA/D0RA10941J#!divAbstract

: https://research.utu.fi/converis/portal/detail/Publication/53410037

In recent years, preparation of fully protected trinucleotide phosphoramidites as synthons for the codon-based synthesis of gene libraries as well as for the assembly of oligonucleotides from blockmers has gained much attention. We here describe the preparation of such trinucleotide synthons on a soluble support using a disulphide linker.

d0ra10941j.pdf