A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Applying Single-Cell Technology in Uveal Melanomas: Current Trends and Perspectives for Improving Uveal Melanoma Metastasis Surveillance and Tumor Profiling
Tekijät: Wang Mona Meng, Chen Chuanfei F, Lynn Myoe Naing, Figueiredo Carlos Rogerio, Tan Wei Jian, Lim Tong Seng, Coupland Sarah E, Chan Anita Sook Yee
Kustantaja: FRONTIERS MEDIA SA
Julkaisuvuosi: 2021
Journal: Frontiers in Molecular Biosciences
Tietokannassa oleva lehden nimi: FRONTIERS IN MOLECULAR BIOSCIENCES
Lehden akronyymi: FRONT MOL BIOSCI
Artikkelin numero: ARTN 611584
Vuosikerta: 7
Sivujen määrä: 10
DOI: https://doi.org/10.3389/fmolb.2020.611584
Rinnakkaistallenteen osoite: https://research.utu.fi/converis/portal/detail/Publication/53390986
Uveal melanoma (UM) is the most common primary adult intraocular malignancy. This rare but devastating cancer causes vision loss and confers a poor survival rate due to distant metastases. Identifying clinical and molecular features that portend a metastatic risk is an important part of UM workup and prognostication. Current UM prognostication tools are based on determining the tumor size, gene expression profile, and chromosomal rearrangements. Although we can predict the risk of metastasis fairly accurately, we cannot obtain preclinical evidence of metastasis or identify biomarkers that might form the basis of targeted therapy. These gaps in UM research might be addressed by single-cell research. Indeed, single-cell technologies are being increasingly used to identify circulating tumor cells and profile transcriptomic signatures in single, drug-resistant tumor cells. Such advances have led to the identification of suitable biomarkers for targeted treatment. Here, we review the approaches used in cutaneous melanomas and other cancers to isolate single cells and profile them at the transcriptomic and/or genomic level. We discuss how these approaches might enhance our current approach to UM management and review the emerging data from single-cell analyses in UM.
Ladattava julkaisu This is an electronic reprint of the original article. |  |
