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Vascular Adhesion Protein-1 Determines the Cellular Properties of Endometrial Pericytes




TekijätGharanei Seley, Fishwick Katherine, Durairaj Ruban Peter, Jin Tianrong, Siamantouras Eleftherios, Liu Kuo-Kang, Straube Anne, Lucas Emma S, Weston Christopher J, Rantakari Pia, Salmi Marko, Jalkanen Sirpa, Brosens Jan J, Tan Bee Kang

KustantajaFRONTIERS MEDIA SA

Julkaisuvuosi2021

JournalFrontiers in cell and developmental biology

Tietokannassa oleva lehden nimiFRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY

Lehden akronyymiFRONT CELL DEV BIOL

Artikkelin numeroARTN 621016

Vuosikerta8

Sivujen määrä11

ISSN2296-634X

DOIhttps://doi.org/10.3389/fcell.2020.621016

Verkko-osoitehttps://www.frontiersin.org/articles/10.3389/fcell.2020.621016/full

Rinnakkaistallenteen osoitehttps://research.utu.fi/converis/portal/Publication/53390372


Tiivistelmä
Vascular adhesion protein-1 (VAP-1) is an inflammation-inducible adhesion molecule and a primary amine oxidase involved in immune cell trafficking. Leukocyte extravasation into tissues is mediated by adhesion molecules expressed on endothelial cells and pericytes. Pericytes play a major role in the angiogenesis and vascularization of cycling endometrium. However, the functional properties of pericytes in the human endometrium are not known. Here we show that pericytes surrounding the spiral arterioles in midluteal human endometrium constitutively express VAP-1. We first characterize these pericytes and demonstrate that knockdown of VAP-1 perturbed their biophysical properties and compromised their contractile, migratory, adhesive and clonogenic capacities. Furthermore, we show that loss of VAP-1 disrupts pericyte-uterine natural killer cell interactions in vitro. Taken together, the data not only reveal that endometrial pericytes represent a cell population with distinct biophysical and functional properties but also suggest a pivotal role for VAP-1 in regulating the recruitment of innate immune cells in human endometrium. We posit that VAP-1 could serve as a potential biomarker for pregnancy pathologies caused by a compromised perivascular environment prior to conception.

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Last updated on 2024-26-11 at 19:30