A1 Refereed original research article in a scientific journal
Maternal haemoglobin levels in pregnancy and child DNA methylation: a study in the pregnancy and childhood epigenetics consortium
Authors: Ronkainen Justiina, Heiskala Anni, Vehmeijer Florianne OL, Lowry Estelle, Caramaschi Doretta, Gutierrez Guadalupe Estrada, Heiss Jonathan A, Hummel Nadine, Keikkala Elina, Kvist Tuomas, Kupsco Allison, Melton PhilipE, Pesce Giancarlo, Soomro Munawar H, Vives-Usano Marta, Baiz Nour, Binder Elizabeth, Czamara Darina, Guxens Mònica, Mustaniemi Sanna, London Stephanie J, Rauschert Sebastian, Vääräsmäki Marja, Vrijheid Martine, Ziegler Anette-G, Annesi-Maesano Isabella, Bustamante Mariona, Huang Rae-Chi, Hummel Sandra, Just Allan C, Kajantie Eero, Lahti Jari, Lawlor Deborah, Räikkönen Katri, Järvelin Marjo-Riitta, Felix Janine F, Sebert Sylvain
Publisher: TAYLOR & FRANCIS INC
Publication year: 2022
Journal: Epigenetics
Journal name in source: EPIGENETICS
Journal acronym: EPIGENETICS-US
Volume: 17
Issue: 1
First page : 19
Last page: 31
Number of pages: 13
ISSN: 1559-2294
eISSN: 1559-2308
DOI: https://doi.org/10.1080/15592294.2020.1864171
Web address : https://www.tandfonline.com/doi/full/10.1080/15592294.2020.1864171
Self-archived copy’s web address: https://research.utu.fi/converis/portal/detail/Publication/53310001
Altered maternal haemoglobin levels during pregnancy are associated with pre-clinical and clinical conditions affecting the fetus. Evidence from animal models suggests that these associations may be partially explained by differential DNA methylation in the newborn with possible long-term consequences. To test this in humans, we meta-analyzed the epigenome-wide associations of maternal haemoglobin levels during pregnancy with offspring DNA methylation in 3,967 newborn cord blood and 1,534 children and 1,962 adolescent whole-blood samples derived from 10 cohorts. DNA methylation was measured using Illumina Infinium Methylation 450K or MethylationEPIC arrays covering 450,000 and 850,000 methylation sites, respectively. There was no statistical support for the association of maternal haemoglobin levels with offspring DNA methylation either at individual methylation sites or clustered in regions. For most participants, maternal haemoglobin levels were within the normal range in the current study, whereas adverse perinatal outcomes often arise at the extremes. Thus, this study does not rule out the possibility that associations with offspring DNA methylation might be seen in studies with more extreme maternal haemoglobin levels.
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