A1 Refereed original research article in a scientific journal
Transpancreatic biliary sphincterotomy versus double guidewire in difficult biliary cannulation: a randomized controlled trial
Authors: Kylänpää Leena, Koskensalo Vilja, Saarela Arto, Ejstrud Per, Udd Marianne, Lindström Outi, Rainio Mia, Tenca Andrea, Halttunen Jorma, Qvigstad Gunnar, Arnelo Urban, Fagerström Niklas, Hauge Truls, Aabakken Lars, Grönroos Juha
Publisher: GEORG THIEME VERLAG KG
Publication year: 2021
Journal: Endoscopy
Journal name in source: ENDOSCOPY
Journal acronym: ENDOSCOPY
Volume: 53
Issue: 10
First page : 1011
Last page: 1019
Number of pages: 9
ISSN: 0013-726X
eISSN: 1438-8812
DOI: https://doi.org/10.1055/a-1327-2025(external)
Web address : https://www.thieme-connect.de/products/ejournals/abstract/10.1055/a-1327-2025(external)
Background Difficult biliary cannulation in endoscopic retrograde cholangiopancreatography (ERCP) increases the risk of post-ERCP pancreatitis (PEP). The purpose of this prospective, randomized, multicenter study was to compare two advanced rescue methods, transpancreatic biliary sphincterotomy (TPBS) and a double-guidewire (DGW) technique, in difficult common bile duct (CBD) cannulation.
Methods Patients with native papilla and planned CBD cannulation were recruited at eight Scandinavian hospitals. An experienced endoscopist attempted CBD cannulation with wire-guided cannulation. If the procedure fulfilled the definition of difficult cannulation and a guidewire entered the pancreatic duct, randomization to either TPBS or to DGW was performed. If the randomized method failed, any method available was performed. The primary end point was the frequency of PEP and the secondary end points included successful cannulation with the randomized method.
Results In total, 1190 patients were recruited and 203 (17.1%) were randomized according to the study protocol (TPBS 104 and DGW 99). PEP developed in 14/104 patients (13.5%) in the TPBS group and 16/99 patients (16.2%) in the DGW group (P=0.69). No difference existed in PEP severity between the groups. The rate of successful deep biliary cannulation was significantly higher with TPBS (84.6% [88/104]) than with DGW (69.7% [69/99]; P=0.01).
Conclusions In difficult biliary cannulation, there was no difference in PEP rate between TPBS and DGW techniques. TPBS is a good alternative in cases of difficult cannulation when the guidewire is in the pancreatic duct.