A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Tenascin-C, GLUT-1, and syndecan-2 expression in juvenile nasopharyngeal angiofibroma: Correlations to vessel density and tumor stage
Tekijät: Renkonen Suvi, Heikkilä Päivi, Haglund Caj, Mäkitie Antti A, Hagström Jaana
Kustantaja: WILEY
Julkaisuvuosi: 2013
Journal: Head and Neck
Tietokannassa oleva lehden nimi: HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
Lehden akronyymi: HEAD NECK-J SCI SPEC
Vuosikerta: 35
Numero: 7
Aloitussivu: 1036
Lopetussivu: 1042
Sivujen määrä: 7
ISSN: 1043-3074
eISSN: 1097-0347
DOI: https://doi.org/10.1002/hed.23083
Tiivistelmä
Background Juvenile nasopharyngeal angiofibroma (JNA) is a highly vascular tumor with some characteristics resembling those of vascular malformations. The significance of different growth and angiogenesis promoting factors for the etiology of JNA remains unsolved.
Methods We analyzed the immunoexpressions of glucose transporter 1 (GLUT-1), tenascin-C (TNC), and syndecan-2 in a series of 27 patients with JNA and compared these with each other and the clinical data to investigate their possible connections and role in the angiogenesis and growth of JNA.
Results We found that frequent stromal TNC expression had a strong correlation with vessel density and tumor stage and endothelial GLUT-1 expression, when present, correlated with higher tumor stage. Stromal TNC and stromal GLUT-1 expressions were also found to correlate with each other. Conclusions The immunoexpression of stromal TNC correlated with vascular density and higher tumors stage, which supports the idea of TNC having a role in the tumorigenesis of JNA putatively by promoting angiogenesis. (c) 2012 Wiley Periodicals, Inc. Head Neck, 2013
Background Juvenile nasopharyngeal angiofibroma (JNA) is a highly vascular tumor with some characteristics resembling those of vascular malformations. The significance of different growth and angiogenesis promoting factors for the etiology of JNA remains unsolved.
Methods We analyzed the immunoexpressions of glucose transporter 1 (GLUT-1), tenascin-C (TNC), and syndecan-2 in a series of 27 patients with JNA and compared these with each other and the clinical data to investigate their possible connections and role in the angiogenesis and growth of JNA.
Results We found that frequent stromal TNC expression had a strong correlation with vessel density and tumor stage and endothelial GLUT-1 expression, when present, correlated with higher tumor stage. Stromal TNC and stromal GLUT-1 expressions were also found to correlate with each other. Conclusions The immunoexpression of stromal TNC correlated with vascular density and higher tumors stage, which supports the idea of TNC having a role in the tumorigenesis of JNA putatively by promoting angiogenesis. (c) 2012 Wiley Periodicals, Inc. Head Neck, 2013
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