A1 Refereed original research article in a scientific journal

Tenascin-C, GLUT-1, and syndecan-2 expression in juvenile nasopharyngeal angiofibroma: Correlations to vessel density and tumor stage




AuthorsRenkonen Suvi, Heikkilä Päivi, Haglund Caj, Mäkitie Antti A, Hagström Jaana

PublisherWILEY

Publication year2013

JournalHead and Neck

Journal name in sourceHEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK

Journal acronymHEAD NECK-J SCI SPEC

Volume35

Issue7

First page 1036

Last page1042

Number of pages7

ISSN1043-3074

eISSN1097-0347

DOIhttps://doi.org/10.1002/hed.23083


Abstract
Background Juvenile nasopharyngeal angiofibroma (JNA) is a highly vascular tumor with some characteristics resembling those of vascular malformations. The significance of different growth and angiogenesis promoting factors for the etiology of JNA remains unsolved. 
Methods We analyzed the immunoexpressions of glucose transporter 1 (GLUT-1), tenascin-C (TNC), and syndecan-2 in a series of 27 patients with JNA and compared these with each other and the clinical data to investigate their possible connections and role in the angiogenesis and growth of JNA. 
Results We found that frequent stromal TNC expression had a strong correlation with vessel density and tumor stage and endothelial GLUT-1 expression, when present, correlated with higher tumor stage. Stromal TNC and stromal GLUT-1 expressions were also found to correlate with each other. Conclusions The immunoexpression of stromal TNC correlated with vascular density and higher tumors stage, which supports the idea of TNC having a role in the tumorigenesis of JNA putatively by promoting angiogenesis. (c) 2012 Wiley Periodicals, Inc. Head Neck, 2013



Last updated on 2024-26-11 at 15:31