Expression of matrix metalloproteinases-2,-8,-13,-26, and tissue inhibitors of metalloproteinase-1 in human osteosarcoma

: Korpi Jaakko T, Hagström Jaana, Lehtonen Niko, Parkkinen Jyrki, Sorsa Timo, Salo Tuula, Laitinen Minna

Publisher: ELSEVIER SCI LTD

: 2011

: Surgical Oncology

: SURGICAL ONCOLOGY-OXFORD

: SURG ONCOL

: 20

: 1

: E18

: E22

: 5

: 0960-7404

DOI: https://doi.org/10.1016/j.suronc.2010.08.004

Osteosarcoma (OS) is among most common malignant tumour of bone. Matrix metalloproteinases (MMPs) are predominantly associated with poor prognosis of several cancers, although some of them, like MMP-8, seem to have a protective role in some cancers. We analyzed the distribution patterns of MMP-2, -8, -13, -26, and tissue inhibitor of matrix metalloproteinase (TIMP)-1 in 25 OS patients. MMP-2, -8, -13, -26 and TIMP-1 were mostly detected in sarcoma cells. Response to chemotherapy affected the amount of MMP-2, -8, and -13 in resection sections when compared to biopsies: patients with excellent or good response had less positivity to MMP-2 in chemotherapy samples than those with moderate or poor response. We conclude that MMP-2, -8, -13, -26, and TIMP-1 are expressed in OS tissue, and all, except protective MMP-8, were also found in metastases indicating that MMPs and TIMP-1 can participate in the OS progression. (C) 2010 Elsevier Ltd. All rights reserved.