A1 Refereed original research article in a scientific journal
Expression of matrix metalloproteinases-2,-8,-13,-26, and tissue inhibitors of metalloproteinase-1 in human osteosarcoma
Authors: Korpi Jaakko T, Hagström Jaana, Lehtonen Niko, Parkkinen Jyrki, Sorsa Timo, Salo Tuula, Laitinen Minna
Publisher: ELSEVIER SCI LTD
Publication year: 2011
Journal: Surgical Oncology
Journal name in source: SURGICAL ONCOLOGY-OXFORD
Journal acronym: SURG ONCOL
Volume: 20
Issue: 1
First page : E18
Last page: E22
Number of pages: 5
ISSN: 0960-7404
DOI: https://doi.org/10.1016/j.suronc.2010.08.004
Abstract
Osteosarcoma (OS) is among most common malignant tumour of bone. Matrix metalloproteinases (MMPs) are predominantly associated with poor prognosis of several cancers, although some of them, like MMP-8, seem to have a protective role in some cancers. We analyzed the distribution patterns of MMP-2, -8, -13, -26, and tissue inhibitor of matrix metalloproteinase (TIMP)-1 in 25 OS patients. MMP-2, -8, -13, -26 and TIMP-1 were mostly detected in sarcoma cells. Response to chemotherapy affected the amount of MMP-2, -8, and -13 in resection sections when compared to biopsies: patients with excellent or good response had less positivity to MMP-2 in chemotherapy samples than those with moderate or poor response. We conclude that MMP-2, -8, -13, -26, and TIMP-1 are expressed in OS tissue, and all, except protective MMP-8, were also found in metastases indicating that MMPs and TIMP-1 can participate in the OS progression. (C) 2010 Elsevier Ltd. All rights reserved.
Osteosarcoma (OS) is among most common malignant tumour of bone. Matrix metalloproteinases (MMPs) are predominantly associated with poor prognosis of several cancers, although some of them, like MMP-8, seem to have a protective role in some cancers. We analyzed the distribution patterns of MMP-2, -8, -13, -26, and tissue inhibitor of matrix metalloproteinase (TIMP)-1 in 25 OS patients. MMP-2, -8, -13, -26 and TIMP-1 were mostly detected in sarcoma cells. Response to chemotherapy affected the amount of MMP-2, -8, and -13 in resection sections when compared to biopsies: patients with excellent or good response had less positivity to MMP-2 in chemotherapy samples than those with moderate or poor response. We conclude that MMP-2, -8, -13, -26, and TIMP-1 are expressed in OS tissue, and all, except protective MMP-8, were also found in metastases indicating that MMPs and TIMP-1 can participate in the OS progression. (C) 2010 Elsevier Ltd. All rights reserved.
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