A1 Refereed original research article in a scientific journal

Large scale statistically validated comorbidity networks;




AuthorsCrisafulli, Paride; Galla, Tobias; Karlsson, Antti; Micciche, Salvatore; Piilo, Jyrki; Mantegna, Rosario N.

PublisherSpringer Science and Business Media LLC

Publication year2026

Journal: EPJ Data Science

Article number50

Volume15

Issue1

eISSN2193-1127

DOIhttps://doi.org/10.1140/epjds/s13688-026-00651-4

Publication's open availability at the time of reportingOpen Access

Publication channel's open availability Open Access publication channel

Web address https://doi.org/10.1140/epjds/s13688-026-00651-4

Self-archived copy’s web addresshttps://research.utu.fi/converis/portal/detail/Publication/526562953

Self-archived copy's licenceCC BY NC ND

Self-archived copy's versionPublisher`s PDF


Abstract

We obtain comorbidity networks starting from medical information stored in electronic health records collected by the Wellbeing Services County of Southwest Finland (Varha). Based on the data, we connect each patient to one or more diseases and construct complex comorbidity networks associated with large patient cohorts characterized by an age interval and sex. The information about diseases in electronic health records is coded using the highest granularity present in the international classification of diseases (ICD codes) provided by the World Health Organization. We statistically validate links in each cohort's comorbidity network and furthermore partition the networks into communities of diseases. These are characterized by the over-expression of a few disease categories, and communities from different age or sex cohorts show various similarities in terms of these disease classes. Moreover, the detected communities for all the cohorts can be organized into a hierarchical tree. This allows us to observe a number of clusters of communities - originating from diverse age and sex cohorts - that group together communities characterized by the same disease classes. We also perform a dismantling procedure of statistically validated comorbidity networks to highlight those categories of diseases that are most responsible for the compactedness of the comorbidity networks for a given cohort of patients.



Keywords:
complex networksStatistically validated networks

Downloadable publication

This is an electronic reprint of the original article.
This reprint may differ from the original in pagination and typographic detail. Please cite the original version.




Funding information in the publication
Fellowship from “la Caixa” Foundation (ID 100010434). The fellowship code is LCF/BQ/DI22/11940041.

Partial financial support from the Agencia Estatal de Investigación and Fondo Europeo de Desarrollo Regional (FEDER, UE) project APASOS (PID2021-122256NB-C21, PID2021-122256NB-C22).

Partial financial support from María de Maeztu program for Units of Excellence, CEX2021-001164-M funded by MCIN/AEI/10.13039/501100011033.

Financial support of the Italian PRIN research project P2022JAYMH “Higher-order complex systems modeling for personalized medicine” funded by NextGenerationEU.


Last updated on 16/06/2026 01:23:50 PM