A1 Refereed original research article in a scientific journal
Blood pressure management in patients receiving rescue stenting after failed endovascular treatment in large vessel occlusion acute ischaemic stroke: a multicentre registry; 
Authors: Anastasiou, Aikaterini; Brehm, Alex; Kaesmacher, Johannes; Mujanovic, Adnan; de Dios Lascuevas, Marta; Carmona, Tomas; López‑Frías, Alfonso; Valverde Hidalgo, Blanca; Nguyen, Thanh N; Abdalkader, Mohamad; Klein, Piers; Thevoz, Guillaume; Michel, Patrik; Bartolini, Bruno; Kaschner, Marius; Weiss, Daniel; Alexandre, Andrea M; Pedicelli, Alessandro; Machi, Paolo; Bernava, Gianmarco; Kuwahara, Shuntaro; Uchida, Kazutaka; Wenderoth, Jason; Joshi, Anirudh; Karwacki, Grzegorz; Bolognese, Manuel; Tessitore, Agostino; Vinci, Sergio Lucio; Cervo, Amedeo; Rollo, Claudia; Hui, Ferdinand; Mozumder, Aaisha Siddiqua; Romano, Daniele Giuseppe; Frauenfelder, Giulia; Goyal, Nitin; Batra, Vivek; Inoa‑Acosta, Violiza; Cognard, Christophe; Hoferica, Matúš; Rautio, Riitta; Kaiser, Daniel P O; Gerber, Johannes C; Clarke, Julian; Levitt, Michael R; Wolf, Marcel N; Othman, Ahmed E; Uphaus, Timo; Scarcia, Luca; Kalsoum, Erwah; Melancia, Diana; de Sousa, Diana Aguiar; Ganimede, Maria Porzia; Semeraro, Vittorio; Giordano, Flavio; Muto, Massimo; Bonala, Umesh; Tuladhar, Anil M; Jenniskens, Sjoerd F M; Hellstern, Victoria; Kleffner, Ilka; Remida, Paolo; Diamanti, Susanna; Renieri, Leonardo; Ballabio, Elena; Valvassori, Luca; Wiesmann, Martin; De Beukelaer, Frederic; Aebischer, Vera; Hoang‑Tho, Dang; Rommers, Nikki; Katan, Mira; Katsanos, Aristeidis H; Psychogios, Marios‑Nikos
Publisher: Oxford University Press (OUP)
Publication year: 2026
Journal: European Stroke Journal
Article number: aakag035
Volume: 11
Issue: 5
ISSN: 2396-9873
eISSN: 2396-9881
DOI: https://doi.org/10.1093/esj/aakag035
Publication's open availability at the time of reporting: Open Access
Publication channel's open availability : Open Access publication channel
Web address : https://doi.org/10.1093/esj/aakag035
Self-archived copy’s web address: https://research.utu.fi/converis/portal/detail/Publication/526513165
Self-archived copy's licence: CC BY
Self-archived copy's version: Publisher`s PDF
Objectives: Rescue stenting (RS) has emerged as a bailout strategy after failed reperfusion during endovascular treatment (EVT). Optimal blood pressure (BP) management after RS remains unclear. Our aim is to evaluate the association of BP levels and blood pressure variability (BPV) during the first 24 h after RS with short-term and long-term patient outcomes.
Methods: We performed a retrospective analysis of an international registry where data from adult patients who underwent either RS or rescue angioplasty after failed EVT were collected. Patients who received RS with large vessel occlusion and at least 4 BP measurements in the first 24 h were included.
Results: RS was performed in 437 patients (40.5% female, mean age 67.1 ± 13 years). Admission median National Institutes of Health Stroke Scale score was 12 (IQR 7-18) and history of hypertension was present in 74.2% of patients. Μean Systolic BP (SBP) in the first 24 h was 137.4 ± 14.6 mmHg. Higher values of BPV (coefficient of variation, standard deviation, average real variability and successive variation) were associated with lower odds for Modified Rankin Scale score 0-2 at 90 days (adjusted odds ratio ranging 0.55 [0.38, 0.79] to 0.99 [0.98, 0.99] per 10 units increase). No associations were found between any SBP measure and death, sICH as well as neurological deterioration at 24 h.
Conclusion: In our study, higher BPV was associated with worse clinical outcomes in stroke patients treated with RS as bailout therapy after failed reperfusion. No association was shown between mean, maximum, minimum and delta SBP and clinical outcomes.
Keywords:
blood pressure management, intracranial atherosclerotic disease, ischaemic stroke, rescue stenting, thrombectomy
Downloadable publication This is an electronic reprint of the original article. |  |
Funding information in the publication:
This study was not funded.
