A1 Refereed original research article in a scientific journal
Bmi-1 expression predicts prognosis in squamous cell carcinoma of the tongue
Authors: Häyry V, Mäkinen LK, Atula T, Sariola H, Mäkitie A, Leivo I, Keski-Santti H, Lundin J, Haglund C, Hagström J
Publisher: NATURE PUBLISHING GROUP
Publication year: 2010
Journal: British Journal of Cancer
Journal name in source: BRITISH JOURNAL OF CANCER
Journal acronym: BRIT J CANCER
Volume: 102
Issue: 5
First page : 892
Last page: 897
Number of pages: 6
ISSN: 0007-0920
DOI: https://doi.org/10.1038/sj.bjc.6605544
Web address : https://www.nature.com/articles/6605544
Abstract
BACKGROUND: The prognosis of squamous cell carcinoma of the oral tongue is poor and it would be beneficial to find prognostic markers to better adjust treatment. Bmi-1 controls cell cycle and self-renewal of tissue stem cells, transcription factor c-myc affects cell proliferation and apoptosis, and Snail regulates epithelial-mesenchymal transition. The expression of these markers has been connected to prognosis in many cancer types.
METHODS: Bmi-1, c-myc, and Snail expressions were studied in our material consisting of 73 primarily T1N0M0 oral tongue carcinoma patients. We compared the immunoexpressions of Bmi1, c-myc, and Snail with clinical parameters including the degree of histological differentiation, tumour size, TNM classification, depth of invasion, and resection margins. In addition, survival analyses were performed, comparing disease-free survival time with the registered protein expression of the markers mentioned above.
RESULTS: A significant correlation between Bmi-1 protein expression and recurrence (log-rank test, P = 0.005) was detected. Snail and c-myc expression did not correlate with prognosis. Snail expression correlated with histopathological grade (Fisher's exact test, P = 0.007) and with the invasion depth of tumours (chi(2)-test, P = 0.037).
CONCLUSION: Negative Bmi-1 immunoexpression might serve as a marker of poor prognosis in oral tongue carcinoma patients. British Journal of Cancer (2010) 102, 892-897. doi: 10.1038/sj.bjc.6605544 www.bjcancer.com Published online 9 February 2010 (C) 2010 Cancer Research UK
BACKGROUND: The prognosis of squamous cell carcinoma of the oral tongue is poor and it would be beneficial to find prognostic markers to better adjust treatment. Bmi-1 controls cell cycle and self-renewal of tissue stem cells, transcription factor c-myc affects cell proliferation and apoptosis, and Snail regulates epithelial-mesenchymal transition. The expression of these markers has been connected to prognosis in many cancer types.
METHODS: Bmi-1, c-myc, and Snail expressions were studied in our material consisting of 73 primarily T1N0M0 oral tongue carcinoma patients. We compared the immunoexpressions of Bmi1, c-myc, and Snail with clinical parameters including the degree of histological differentiation, tumour size, TNM classification, depth of invasion, and resection margins. In addition, survival analyses were performed, comparing disease-free survival time with the registered protein expression of the markers mentioned above.
RESULTS: A significant correlation between Bmi-1 protein expression and recurrence (log-rank test, P = 0.005) was detected. Snail and c-myc expression did not correlate with prognosis. Snail expression correlated with histopathological grade (Fisher's exact test, P = 0.007) and with the invasion depth of tumours (chi(2)-test, P = 0.037).
CONCLUSION: Negative Bmi-1 immunoexpression might serve as a marker of poor prognosis in oral tongue carcinoma patients. British Journal of Cancer (2010) 102, 892-897. doi: 10.1038/sj.bjc.6605544 www.bjcancer.com Published online 9 February 2010 (C) 2010 Cancer Research UK
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