A2 Vertaisarvioitu katsausartikkeli tieteellisessä lehdessä

RNA signaling in cellular plasticity during homeostasis and regeneration;



Tekijät: Nagaraj, Ajai C.; Ahi, Ehsan P.; Änkö, Minna-Liisa; Kaslin, Jan

Kustantaja: Elsevier

Julkaisuvuosi: 2026

Lehti: Current Opinion in Genetics and Development

Artikkelin numero: 102478

Vuosikerta: 99

ISSN: 0959-437X

eISSN: 1879-0380

DOI: https://doi.org/10.1016/j.gde.2026.102478

Julkaisun avoimuus kirjaamishetkellä: Avoimesti saatavilla

Julkaisukanavan avoimuus : Osittain avoin julkaisukanava

Verkko-osoite: https://doi.org/10.1016/j.gde.2026.102478

Rinnakkaistallenteen osoite: https://research.utu.fi/converis/portal/detail/Publication/523468752

Rinnakkaistallenteen lisenssi: CC BY

Rinnakkaistallennetun julkaisun versio: Kustantajan versio


Tiivistelmä

Cells and tissues constantly read and broadcast information through RNA. This mini-review explores how endogenous and damage-released RNAs act as instructive signals that rewire cell identity during steady-state homeostasis and injury repair. We will cover how repetitive-element-derived RNAs and regulatory long-noncoding RNAs (lncRNAs) tune stem and progenitor plasticity in hematopoietic, pluripotent, and muscle systems by coupling stress sensing to cell-fate decisions. We will also outline extracellular dsRNA/TLR3 signaling and injury-induced lncRNAs in epithelial, neural, cardiac, and vascular regeneration, and show how extracellular RNA shapes inflammatory and stromal responses. Together, these concepts present RNA as an active rheostat of cellular plasticity across development, tissue maintenance, and regeneration.


Ladattava julkaisu

This is an electronic reprint of the original article.
This reprint may differ from the original in pagination and typographic detail. Please cite the original version.

Julkaisussa olevat rahoitustiedot: 
This work was supported by the Victorian Government Operational Infrastructure Support Scheme [MLÄ], Biocenter Finland [to JK, MLÄ, AN, and EPA], National Health and Medical Research Council (NHMRC) [GNT2013305, GNT2037953 to JK], Sigrid Juselius Foundation [to JK and MLÄ], Research Council of Finland [to JK and MLÄ], and Australian Research Council (ARC) Discovery Grant [DP210103501 to JK].


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