A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Matrix metalloproteinase-7, -8, -9, -15, and -25 in minor salivary gland adenoid cystic carcinoma
Tekijät: Hämetoja Hanna, Mäkitie Antti, Bäck Leif, Leivo Ilmo, Haglund Caj, Sorsa Timo, Hagström Jaana
Kustantaja: Elsevier GmbH
Julkaisuvuosi: 2021
Journal: Pathology - Research and Practice
Tietokannassa oleva lehden nimi: Pathology Research and Practice
Artikkelin numero: 153293
Vuosikerta: 217
eISSN: 1618-0631
DOI: https://doi.org/10.1016/j.prp.2020.153293
Rinnakkaistallenteen osoite: https://research.utu.fi/converis/portal/detail/Publication/52328213
Knowledge on the role of matrix metalloproteinases (MMPs) in adenoid cystic carcinoma (ACC) is limited. MMPs are capable of degrading almost all extracellular and pericellular components to promote invasion and metastasis. This study aimed to evaluate the immunohistochemical expression of MMP-7, -8, -9, -15, and -25 in ACC and to relate the results with clinicopathological factors and survival.
The study included 68 patients with minor salivary gland ACC treated at the Helsinki University Hospital (Helsinki, Finland) in 1974–2012. Samples from 52 patients were available, consisting of 44 primary tumours and eight recurrent tumours. We scored immunostaining of MMP-7, -8, -9, -15, and -25 and analysed the immunoscore against clinical and pathological parameters using statistical correlation test.
MMP-9 immunoexpression in pseudocysts of ACC and in peritumoural inflammatory cells associated with better survival and fewer treatment failures. High tumoural MMP-7 and -25 associated with better survival. High tumoural MMP-15 associated with poorer survival and high tumoural MMP-9 with advanced stage and regional recurrences. Tumour cells did not show MMP-8 immunopositivity.
These results suggest that MMP-9 may contribute to ACC carcinogenesis in different roles. MMP-7, -8, and -9 can stimulate signalling pathways that may promote tissue modulation and metastatic potential. MMP-15 and -25 may reflect prognosis.
Ladattava julkaisu This is an electronic reprint of the original article. |