A1 Refereed original research article in a scientific journal

ONWARD: A one health, pan-European multidisciplinary network advancing surveillance, research, clinical management and control of zoonotic hepeviruses




AuthorsRivero-Juarez, Antonio; Velebit, Branko; Johne, Reimar; Abravanel, Florence; Reuter, Gabor; Dudman, Susanne; Kamar, Nassim; Jemersic, Lorena; di Bartolo, Ilaria; Hasanoglu, Imran; Anita, Adriana; Cook, Nigel; Ruta, Simona; Nauwelaers, Inne; Milojević, Lazar; Todorovska, Elena; Mojsova, Sandra; Zerja, Arjana; Avellon, Ana; Hakze-van der Honing, Renate; Harvala, Heli; Sao Jose Nascimento, Maria; Mesquita, Joao R.; members of ONWARD

PublisherElsevier

Publication year2026

Journal: Journal of Clinical Virology

Article number105944

Volume184

ISSN1386-6532

eISSN1873-5967

DOIhttps://doi.org/10.1016/j.jcv.2026.105944

Publication's open availability at the time of reportingOpen Access

Publication channel's open availability Partially Open Access publication channel

Web address https://doi.org/10.1016/j.jcv.2026.105944

Self-archived copy’s web addresshttps://research.utu.fi/converis/portal/detail/Publication/523223464

Self-archived copy's licenceCC BY NC

Self-archived copy's versionPublisher`s PDF


Abstract

Zoonotic hepeviruses, particularly hepatitis E virus (HEV, species Paslahepevirus balayani) represent a major yet underestimated public health challenge in Europe. Despite being the leading cause of acute viral hepatitis, surveillance, diagnostic practices and prevention strategies remain heterogeneous across EU/EEA countries, limiting comparability and hindering accurate burden estimates. Underdiagnosis is further compounded by extrahepatic manifestations and the growing impact of chronic HEV infection in immunocompromised patients. At the human–animal–environment interface, zoonotic HEV circulates widely in domestic pigs, wildlife and food products, while coordinated surveillance and control measures remain inconsistently implemented. The recent recognition of ratHEV (species Rocahepevirus ratti) as a cause of acute and chronic hepatitis in Europe further expands the spectrum of zoonotic hepevirus infections and underscores the need for integrated One Health approaches. To address these challenges, the One Health Zoonotic Hepevirus Network (ONWARD; COST Action CA24140) was launched in 2025 as a pan-European, multidisciplinary collaboration uniting experts across human, veterinary, food safety and environmental health sectors. ONWARD aims to harmonise diagnostic tools, strengthen clinical research, integrate multisectoral surveillance, promote capacity building and support evidence-based policy development. By fostering coordination with European stakeholders ONWARD provides a structured framework to strengthen preparedness, surveillance and response to zoonotic hepevirus threats across Europe.


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Funding information in the publication
This article is based upon work from COST Action CA24140 – ONWARD: One Health Zoonotic Hepevirus Network, supported by COST (European Cooperation in Science and Technology, www.cost.eu)


Last updated on 07/05/2026 11:52:52 AM