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A Follow-Up Study on 6-[(18)F]Fluoro-L-dopa Uptake in Early Parkinson's Disease Shows Nonlinear Progression in the Putamen
Tekijät: Bruck A, Aalto S, Rauhala E, Bergman J, Marttila R, Rinne JO
Kustantaja: WILEY-LISS
Julkaisuvuosi: 2009
Journal: Movement Disorders
Tietokannassa oleva lehden nimi: MOVEMENT DISORDERS
Lehden akronyymi: MOVEMENT DISORD
Vuosikerta: 24
Numero: 7
Aloitussivu: 1009
Lopetussivu: 1015
Sivujen määrä: 7
ISSN: 0885-3185
DOI: https://doi.org/10.1002/mds.22484
Tiivistelmä
Sixteen subjects with de novo Parkinso's disease (PD) underwent three 6-[18F]fluoro-L-dopa (Fdopa) positron emission tomography (PET) scans during a follow-up time of 5 years (mean +/- SD 5.5 +/- 0.4 years) to study the progression of striatal dopaminergic hypofunction. Throughout the study, the smallest Fdopa uptake values were found in the dorso-caudan part of the putamen contralateral to the side with dominant motor symptoms. The rate of decline in Fdopa uptake in the contralateral putamen was faster in the begining of the disease and slowed down as the disease progressed. The annual decline in Fdopa influx constant (ki, unit x 10(-3) min(-1)) was on average 0.5 during the first 2 years and 0.2 during the subsequent 3 years (P = 0.002) in the contralateral putamen. IN caudate, the rate of decline in Fdopa values was slower than in the putamen and did not change significantly during the follow-up time, annual decline in the contralateral caudate being 0.1 between base-line and 2 years and 0.3 between 2 and 5 years (P = 0.4). These results suggest that progression of putaminal dopaminergic hypofunction in PD follows a nonlinear pattern at least in the contralateral side being faster in the beginning of the disease. (C) 2009 Movement Disorder Society
Sixteen subjects with de novo Parkinso's disease (PD) underwent three 6-[18F]fluoro-L-dopa (Fdopa) positron emission tomography (PET) scans during a follow-up time of 5 years (mean +/- SD 5.5 +/- 0.4 years) to study the progression of striatal dopaminergic hypofunction. Throughout the study, the smallest Fdopa uptake values were found in the dorso-caudan part of the putamen contralateral to the side with dominant motor symptoms. The rate of decline in Fdopa uptake in the contralateral putamen was faster in the begining of the disease and slowed down as the disease progressed. The annual decline in Fdopa influx constant (ki, unit x 10(-3) min(-1)) was on average 0.5 during the first 2 years and 0.2 during the subsequent 3 years (P = 0.002) in the contralateral putamen. IN caudate, the rate of decline in Fdopa values was slower than in the putamen and did not change significantly during the follow-up time, annual decline in the contralateral caudate being 0.1 between base-line and 2 years and 0.3 between 2 and 5 years (P = 0.4). These results suggest that progression of putaminal dopaminergic hypofunction in PD follows a nonlinear pattern at least in the contralateral side being faster in the beginning of the disease. (C) 2009 Movement Disorder Society
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