A1 Refereed original research article in a scientific journal
A Follow-Up Study on 6-[(18)F]Fluoro-L-dopa Uptake in Early Parkinson's Disease Shows Nonlinear Progression in the Putamen
Authors: Bruck A, Aalto S, Rauhala E, Bergman J, Marttila R, Rinne JO
Publisher: WILEY-LISS
Publication year: 2009
Journal: Movement Disorders
Journal name in source: MOVEMENT DISORDERS
Journal acronym: MOVEMENT DISORD
Volume: 24
Issue: 7
First page : 1009
Last page: 1015
Number of pages: 7
ISSN: 0885-3185
DOI: https://doi.org/10.1002/mds.22484
Abstract
Sixteen subjects with de novo Parkinso's disease (PD) underwent three 6-[18F]fluoro-L-dopa (Fdopa) positron emission tomography (PET) scans during a follow-up time of 5 years (mean +/- SD 5.5 +/- 0.4 years) to study the progression of striatal dopaminergic hypofunction. Throughout the study, the smallest Fdopa uptake values were found in the dorso-caudan part of the putamen contralateral to the side with dominant motor symptoms. The rate of decline in Fdopa uptake in the contralateral putamen was faster in the begining of the disease and slowed down as the disease progressed. The annual decline in Fdopa influx constant (ki, unit x 10(-3) min(-1)) was on average 0.5 during the first 2 years and 0.2 during the subsequent 3 years (P = 0.002) in the contralateral putamen. IN caudate, the rate of decline in Fdopa values was slower than in the putamen and did not change significantly during the follow-up time, annual decline in the contralateral caudate being 0.1 between base-line and 2 years and 0.3 between 2 and 5 years (P = 0.4). These results suggest that progression of putaminal dopaminergic hypofunction in PD follows a nonlinear pattern at least in the contralateral side being faster in the beginning of the disease. (C) 2009 Movement Disorder Society
Sixteen subjects with de novo Parkinso's disease (PD) underwent three 6-[18F]fluoro-L-dopa (Fdopa) positron emission tomography (PET) scans during a follow-up time of 5 years (mean +/- SD 5.5 +/- 0.4 years) to study the progression of striatal dopaminergic hypofunction. Throughout the study, the smallest Fdopa uptake values were found in the dorso-caudan part of the putamen contralateral to the side with dominant motor symptoms. The rate of decline in Fdopa uptake in the contralateral putamen was faster in the begining of the disease and slowed down as the disease progressed. The annual decline in Fdopa influx constant (ki, unit x 10(-3) min(-1)) was on average 0.5 during the first 2 years and 0.2 during the subsequent 3 years (P = 0.002) in the contralateral putamen. IN caudate, the rate of decline in Fdopa values was slower than in the putamen and did not change significantly during the follow-up time, annual decline in the contralateral caudate being 0.1 between base-line and 2 years and 0.3 between 2 and 5 years (P = 0.4). These results suggest that progression of putaminal dopaminergic hypofunction in PD follows a nonlinear pattern at least in the contralateral side being faster in the beginning of the disease. (C) 2009 Movement Disorder Society
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