A2 Vertaisarvioitu katsausartikkeli tieteellisessä lehdessä
Engineering the Liquid‐to‐Solid Transition of Biomolecular Condensates: Molecular Mechanisms, Control Strategies, and Applications
Tekijät: Yin, Chengying; Chen, Chong; Yu, Xinran; Wu, Shuqi; Lin, Zi; Xu, Li; Wang, Xuejing
Kustantaja: Wiley
Julkaisuvuosi: 2026
Lehti: Small
Artikkelin numero: e73582
ISSN: 1613-6810
eISSN: 1613-6829
DOI: https://doi.org/10.1002/smll.73582
Julkaisun avoimuus kirjaamishetkellä: Ei avoimesti saatavilla
Julkaisukanavan avoimuus : Osittain avoin julkaisukanava
Verkko-osoite: https://doi.org/10.1002/smll.73582
Tiivistelmä
Biomolecular condensates are formed through liquid-liquid phase separation (LLPS). They are highly dynamic, membraneless compartments within cells. The liquid-to-solid transition (LST) of these condensates plays a central role in regulating cellular physiological functions, maintaining tissue structural stability, and driving disease progression. Engineering LST has emerged as a major research frontier, integrating biophysics, synthetic biology, and materials science. This review systematically outlines the molecular grammar governing LST, key engineering strategies for its spatiotemporal control, and emerging applications in designed biological systems. We further discuss current challenges and future directions for harnessing LST as a design principle in systems chemistry and synthetic biology.
Biomolecular condensates are formed through liquid-liquid phase separation (LLPS). They are highly dynamic, membraneless compartments within cells. The liquid-to-solid transition (LST) of these condensates plays a central role in regulating cellular physiological functions, maintaining tissue structural stability, and driving disease progression. Engineering LST has emerged as a major research frontier, integrating biophysics, synthetic biology, and materials science. This review systematically outlines the molecular grammar governing LST, key engineering strategies for its spatiotemporal control, and emerging applications in designed biological systems. We further discuss current challenges and future directions for harnessing LST as a design principle in systems chemistry and synthetic biology.
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