A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Enhanced Neutralizing Antibody Responses to Rhinovirus C and Age-Dependent Patterns of Infection
Tekijät: Choi Timothy, Devries Mark, Bacharier Len, Busse William, Camargo Jr. Carlos A, Cohen Robyn, Demuri Gregory P, Evans Michael D., Fitzpatrick Anne M, Gergen Peter J, Grindle Kristine, Gruchalla Rebecca, Hartert Tina, Hasegawa Kohei, Hershey Gurjit K. Khurana, Holt Patrick, Homil Kiara, Jartti Tuomas, Kattan Meyer, Kercsmar Carolyn, Kim Haejin, Laing Ingrid A, LeBeau Petra, Lee Kristine E., Le Souëf Peter N., Liu Andrew, Mauger David T., Ober Carole, Pappas Tressa, Patel Shilpa J., Phipatanakul Wanda, Pongracic Jacqueline, Seroogy Christine, Sly Peter D, Tisler Christopher, Wald Ellen R, Wood Robert, Gangnon Ronald, Jackson Daniel J, Lemanske Jr Robert F, Gern James E., Bochkov Yury A.; and on behalf of program collaborators for Environmental influences on Child Health Outcomes
Kustantaja: American Lung Association
Julkaisuvuosi: 2021
Journal: American Journal of Respiratory and Critical Care Medicine
Tietokannassa oleva lehden nimi: American journal of respiratory and critical care medicine
Lehden akronyymi: Am J Respir Crit Care Med
Vuosikerta: 203
Numero: 7
Aloitussivu: 822
Lopetussivu: 830
ISSN: 1073-449X
eISSN: 1535-4970
DOI: https://doi.org/10.1164/rccm.202010-3753OC
Rinnakkaistallenteen osoite: https://research.utu.fi/converis/portal/detail/Publication/52209498
Knowledge of prevalent RV types, antibody responses, and populations at risk based on age and genetics may guide the development of vaccines or other novel therapies against this important respiratory pathogen.Longitudinal data from the Childhood Origins of ASThma (COAST) birth cohort study were analyzed to determine relationships between age and RV-C infections. Neutralizing antibodies specific for rhinovirus A (RV-A) and RV-C (3 types each) were determined using a novel polymerase chain reaction-based assay. We pooled data from 14 study cohorts in the United States, Finland, and Australia and used mixed-effects logistic regression to identify factors related to the proportion of RV-C versus RV-A detection.In COAST, RV-A and RV-C infections were similarly common in infancy, while RV-C was detected much less often than RV-A during both respiratory illnesses and scheduled surveillance visits (p<0.001, chi-square) in older children. The prevalence of neutralizing antibodies to RV-A or RV-C types was low (5%-27%) at age 2 years, but by age 16, RV-C seropositivity was more prevalent (78% vs. 18% for RV-A, p<0.0001). In the pooled analysis, the RV-C to RV-A detection ratio during illnesses was significantly related to age (p<0.0001), CDHR3 genotype (p<0.05), and wheezing illnesses (p<0.05). Furthermore, certain RV types (e.g., C2, C11, A78, A12) were consistently more virulent and prevalent over time.Rhinovirus C (RV-C) can cause asymptomatic infection and respiratory illnesses ranging from the common cold to severe wheezing.To identify how age and other individual-level factors are associated with susceptibility to RV-C illnesses.
Ladattava julkaisu This is an electronic reprint of the original article. |  |
