HERITABLE DENTIN DEFECTS - NOSOLOGY, PATHOLOGY, AND TREATMENT



: RANTA H, LUKINMAA PL, WALTIMO J

Publisher: WILEY-LISS

: 1993

: American journal of medical genetics

: AMERICAN JOURNAL OF MEDICAL GENETICS

: AM J MED GENET

: 45

: 2

: 193

: 200

: 8

: 0148-7299

DOI: https://doi.org/10.1002/ajmg.1320450209


Heritable dentin defects have been divided into 2 main categories: dentinogenesis imperfecta (DI) and dentin dysplasia (DD). Recent studies have shown that they share many features in common. Of the connective tissue diseases, only osteogenesis imperfecta (OI) has been linked to these disorders. So far, no definitive relation between the type of OI and the dental involvement can be established. Familial occurrence of DI with OI cannot be comprehensively explained by mutations in type I collagen genes. No information about the gene defects in DD is available. At the ultrastructural level, the organization of the normally cross-striated collagen fibers in the dentin matrix varies markedly in patients affected by DI.



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