A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Maternal pre- and postnatal depression and anxiety: Impacts on childhood asthma and its phenotypes
Tekijät: Kanerva, Eetu; Lukkarinen, Minna; Leppänen, Marika; Pape, Bernd; Rautava, Päivi; Karukivi, Max
Kustantaja: Elsevier BV
Julkaisuvuosi: 2026
Lehti: Journal of Psychosomatic Research
Artikkelin numero: 112610
Vuosikerta: 204
ISSN: 0022-3999
eISSN: 1879-1360
DOI: https://doi.org/10.1016/j.jpsychores.2026.112610
Julkaisun avoimuus kirjaamishetkellä: Avoimesti saatavilla
Julkaisukanavan avoimuus : Osittain avoin julkaisukanava
Verkko-osoite: https://doi.org/10.1016/j.jpsychores.2026.112610
Rinnakkaistallenteen osoite: https://research.utu.fi/converis/portal/detail/Publication/515878019
Rinnakkaistallenteen lisenssi: CC BY
Rinnakkaistallennetun julkaisun versio: Kustantajan versio
BackgroundMaternal psychological distress during pregnancy is known to elevate the risk of offspring asthma, but the impact of the timing of the distress remains poorly understood.ObjectivesTo assess the individual and combined effects of maternal prenatal and postnatal depressive and anxiety disorders, both separately and longitudinally, on offspring asthma and its phenotypes.MethodsHealthcare register data on 310,701 children born 2001–2006 and their 232,240 mothers were collected. Maternal depressive disorder was defined by diagnoses F30, F31, F32–F34 and F38 and anxiety disorder as F40–F42, F44–F45 and F48. Timing of disorder was defined as prenatal (from one year before until labor) and postnatal periods (from birth until three years postpartum). Child outcomes were overall asthma diagnosis J45–J46 at 7–12 years, further separated into allergic J45.0 and non-allergic J45.1 asthma phenotypes.ResultsAltogether, 19,000 (6.1%) children had asthma, 6517 (2.8%) mothers had depression, and 4189 (1.8%) had anxiety disorder. Child overall asthma was associated with maternal prenatal depression (adjusted odds ratio 1.28; 95% confidence interval 1.08–1.53) and anxiety disorders (1.30; 1.07–1.57), and with postnatal anxiety disorders (1.33; 1.15–1.54). Both maternal postnatal depression (1.36; 1.06–1.74) and anxiety disorders (1.45; 1.06–2.00) were associated with non-atopic asthma, and postnatal anxiety was associated with atopic asthma (1.34; 1.07–1.67). The comorbidity or longitudinality of maternal depressive and anxiety disorders didn't affect the associations.ConclusionMaternal depressive and anxiety disorders were associated with offspring asthma, varying by phenotype and timing. The postnatal effect was significant, suggesting independent associations and possibly distinct pathways in child respiratory morbidity.
Ladattava julkaisu This is an electronic reprint of the original article. |  |
Julkaisussa olevat rahoitustiedot:
The study was conducted independently of the funding sources, which had no role in its design, data collection, analysis or interpretation, execution, nor in the preparation, writing, review, approval or submission of the manuscript for publication. The funding sources among the authors were the following: the Ministry of Social Affairs and Health of Finland, Helsinki (Päivi Rautava, Marika Leppänen), State Funding for University Level Research of Health (P¨ aivi Rautava), the Finnish State Grants for Clinical Research (P¨ aivi Rautava), Signe and Ane Gyllenberg Foundation, Helsinki (Eetu Kanerva) and the Finnish Allergy, Skin and Asthma Foundation, Helsinki (Eetu Kanerva) - all in Finland.
