A1 Refereed original research article in a scientific journal
Isomeric cues direct macrocycle selection from complex chemical systems for selective separation and recycling
Authors: Wang, Xin; Yang, Jinghui; Rosqvist, Emil; Lyu, Yonglei; Papageorgiou, Anastassios C.; Peltonen, Jouko; Mäkilä, Ermei; Cheng, Fangyi; Li, Jianwei
Publisher: Cell Press
Publication year: 2026
Journal: Cell Reports Physical Science
Article number: 103140
Volume: 7
eISSN: 2666-3864
DOI: https://doi.org/10.1016/j.xcrp.2026.103140
Publication's open availability at the time of reporting: Open Access
Publication channel's open availability : Open Access publication channel
Web address : https://doi.org/10.1016/j.xcrp.2026.103140
Self-archived copy’s web address: https://research.utu.fi/converis/portal/detail/Publication/515791505
Self-archived copy's licence: CC BY NC
Self-archived copy's version: Publisher`s PDF
Living systems translate subtle molecular variations into functional complexity through selective recognition and hierarchical self-assembly. Here, we report that dynamic combinatorial chemistry (DCC) can amplify minute structural differences among isomeric templates, guiding templated selection toward distinct supramolecular outcomes. Using a dithiol building block, a library of macrocycles is generated, within which only one isomeric template selectively amplifies the tetrameric macrocycle. Their co-assembly produces highly ordered 2D nanosheets that spontaneously precipitate, enabling facile component separation. This selective organization contrasts with the simple 1:1 complex formed by other isomers, underscoring the sensitivity of dynamic systems to small structural cues. Significantly, both the template and the amplified species are recovered with high efficiency, allowing material recyclability. These findings reveal how dynamic molecular systems transform subtle information into functional architectures, offering a conceptual model for templated selection and a strategy for the design of adaptive supramolecular materials featuring selective recognition, separation, and reuse.
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Funding information in the publication:
We are grateful for financial support from the National Natural Science Foundation of China (22161016) and Sigrid Jusélius Foundation (Senior Researcher Fellowship). X.W. and J.Y. acknowledge support from the China Scholarship Council.
