A1 Refereed original research article in a scientific journal

Intraoperative Hypotension and Vasoactive Treatment: An International Survey of Anaesthesiologists




AuthorsBækgaard, Emilie S.; Vester‐Andersen, Morten; Crone, Vera; Hylander Møller, Morten; Yamanaka, Shun; Palmarsdottir, Rakel; Uusalo, Panu; Haidl, Felix; Rådestad, Madeleine; van der Sloot, Koene; Corona, Andrea; Johnström, Alexander; Nørskov, Anders Kehlet; Karlsen, Anders P. H.; Isberg Faustad, Birgit; Borgen Sørensen, Christina; Spies, Fabian; Bjarkhamar Krogh, Hanna; El‐Hallak, Hayan; Møller Mistry, Jacqueline; Kjerulff Mønnich, Julie; Grangård Olesen, Karen; Madsen, Karl P. D.; Lerche Voogd, Kirsten; Mulla Reich, Laila; Agger Kolstrup, Line; Juhl‐Olsen, Peter; Korsgaard Körner, Luisa; Ingi Sigurdsson, Martin; Jensen‐Holm, Mathias Bach; Slavensky, Julie Anna; Toft, Mette Helene; Jørgensen, Michael Leth; Andersen, Mikkel; Jensen, Mikkel Schiødt Heide; Saei, Mojtaba; Hedetoft, Morten; Hansen, Peter Martin; Hansen, Rasmus Tofte; Lundsgaard, Rune Sarauw; Krarup, Sarah Marie Ivan; Wiberg, Sebastian; Laustrup, Torben; Brizzi, Guilia; Kreutziger, Janett; Onyemuchara, Ifunanya; Adeniji, Adebisi; Colville, Thomas; Keitley, James A.; Khan, Meherunissa; Millar, Morven; Lennie, Iona; Kelly, Kieran; Brooker, Verity; Roberts, Jack; Lipton, Gareth; Keohone, Jill; Chebbout, Ryad; Bond, Oliver; Milligan, William; O'Brien, Ciara; Wright, Edward; Linton, Fiona; Towell, Charlotte; Shuttleworth, James; Norton, James; Butler, Daniel; Frankland, Stuart; Screech, Francis; Charig, Lucy; Walsh, Stephanie; Davies, Rhys; Jones, Eleanor; Dalmonte, Elodia; Evans, Matthew; Krag, Mette

PublisherWiley

Publication year2026

Journal: Acta Anaesthesiologica Scandinavica

Article numbere70197

Volume70

Issue3

ISSN0001-5172

eISSN1399-6576

DOIhttps://doi.org/10.1111/aas.70197

Publication's open availability at the time of reportingOpen Access

Publication channel's open availability Partially Open Access publication channel

Web address https://doi.org/10.1111/aas.70197

Self-archived copy’s web addresshttps://research.utu.fi/converis/portal/detail/Publication/515607276

Self-archived copy's licenceCC BY NC ND

Self-archived copy's versionPublisher`s PDF


Abstract
Background

Intraoperative hypotension is a common occurrence in patients undergoing anaesthesia, although there is no standardised definition of hypotension. International consensus statements provide some guidelines for the management of intraoperative hypotension, but general clinical practice is unknown. We aimed to survey anaesthesiologists' values and preferences regarding intraoperative blood pressure management, including whether they would support future research on this topic.

Methods

We conducted an international, online survey of routine practice and opinion. The target population was anaesthesiologists who regularly anaesthetise adult patients. Results are reported descriptively and in accordance with the Consensus-Based Checklist for Reporting of Survey Studies (CROSS) checklist.

Results

A total of 1640 anaesthesiologists from 11 European countries participated in the survey. The majority of respondents were specialists (1322 of 1640, 80.6%, 95% CI 78.7–82.6). Almost all respondents worked in public hospitals (1613 of 1640, 98.4%). The overall response rate was 22.7%. Most respondents reported using absolute mean arterial pressure as their main unit of measurement to quantify hypotension (1098 of 1640, 67.0%, 95% CI 64.6–69.2). Respondents were most likely to initiate vasoactive treatment at a mean arterial pressure below 60 or 65 mmHg. Chronic arterial hypertension, traumatic brain injury and surgical procedures involving head-up positioning of the patient were the three most common scenarios where respondents would raise their threshold for treatment. Most respondents considered the establishment of safe intraoperative blood pressure thresholds a critical research question, and almost all respondents (1509 of 1640, 92.0%) indicated a willingness to randomise patients to specific blood pressure targets. For 72.9% (1196 of 1640), the lowest acceptable mean arterial pressure for randomisation was 60 mmHg. Respondents were also interested in the comparison of efficacy and safety of vasoactive agents, and the most sought-after comparison was phenylephrine versus noradrenaline (1252 of 1640, 76.3%). The willingness of respondents to administer these agents in peripheral venous access differed according to geography.

Conclusion

In this international survey, mean arterial pressures of 60 or 65 mmHg were the most commonly reported blood pressure thresholds leading to initiation of treatment with vasoactive agents. Almost all respondents indicated patient groups for whom they would alter their treatment threshold, namely those suffering from chronic arterial hypertension, those undergoing surgery in a head-up position, and patients with traumatic brain injury. The majority of respondents supported future trials establishing optimal mean arterial pressure threshold and choice of vasoactive agent. We noticed a geographical variation in willingness to administer vasoactive agents in peripheral venous access.


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Funding information in the publication
The authors received salary funding from their respective departments. E.S.B. received a research grant from the “Læge Sofus Carl Emil Friis og Hustru Olga Doris Friis' Legat” foundation for this project.


Last updated on 25/02/2026 12:17:28 PM