A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Preterm Birth Is Associated With Depression From Childhood to Early Adulthood

Julkaisun tekijät: Upadhyaya Subina, Sourander Andre, Luntamo Terhi, Matinolli Hanna-Maria, Chudal Roshan, Hinkka-Yli-Salomäki Susanna, Filatova Svetlana, Cheslack-Postava Keely, Sucksdorff Minna, Gissler Mika, Brown Alan, Lehtonen Liisa

Julkaisuvuosi: 2020

Journal: Journal of the American Academy of Child and Adolescent Psychiatry

DOI: http://dx.doi.org/10.1016/j.jaac.2020.09.020



There have been inconsistent findings on the associations between
prematurity, poor fetal growth and depression. We examined the
associations between gestational age, poor fetal growth and depression
in individuals aged 5 to 25 years.


We identified 37,682 cases based on ICD-9 code 2961 and ICD-10
codes F32.0-F32.9 and F33.0-F33.9 from the Care Register for Health
Care, and 148,795 matched controls from the Finnish Central Population
Register. Conditional logistic regression examined the associations
between gestational age by each gestational week, poor fetal growth and
depression. The associations were adjusted for parental age and
psychopathology, paternal immigrant status, maternal substance abuse,
depression, number of previous births, marital status, socio-economic
status, smoking during pregnancy and the infant's birthplace.


In the adjusted models, increased risk of depression was found in
children born ≤ 25 weeks (1.89, 1.08-3.31), at 26 weeks (2.62,
1.49-4.61), at 27 weeks (1.93, 1.05-3.53) and ≥ 42 weeks (1.11,
1.05-1.19). In girls, extremely preterm birth was associated with
depression diagnosed at 5 to 12 years (2.70, 1.83-3.98) and 13 to 18
years (2.97, 1.84-4.78). In boys, post-term birth (≥42 weeks) was
associated with depression diagnosed at 19 to 25 years (1.28,
1.07-1.54). Poor fetal growth was associated with an increased risk of
depression in full-term infants (1.06, 1.03-1.10) and post-term infants
(1.24, 1.08-1.43).


Preterm birth before 28 weeks of gestation appeared to play a role
in the development of childhood depression. Smaller effects were also
seen in post-term births, especially in boys.

Last updated on 2021-24-06 at 08:34