A1 Refereed original research article in a scientific journal
Childhood BMI and Fasting Glucose and Insulin Predict Adult Type 2 Diabetes: The International Childhood Cardiovascular Cohort (i3C) Consortium
Authors: Hu Tian, Jacobs David R, Sinaiko Alan R, Bazzano Lydia A, Burns Trudy L, Daniels Stephen R, Dwyer Terry, Hutri-Kähonen Nina, Juonala Markus, Murdy Kari A, Prineas Ronald J, Raitakari Olli T, Urbina Elaine M, Venn Alison, Woo Jessica G, Steinberger Julia
Publisher: AMER DIABETES ASSOC
Publication year: 2020
Journal: Diabetes Care
Journal name in source: DIABETES CARE
Journal acronym: DIABETES CARE
Volume: 43
Issue: 11
First page : 2821
Last page: 2829
Number of pages: 9
ISSN: 0149-5992
eISSN: 1935-5548
DOI: https://doi.org/10.2337/dc20-0822
Self-archived copy’s web address: https://research.utu.fi/converis/portal/detail/Publication/51436304
OBJECTIVE To examine childhood BMI, fasting glucose, and insulin in relation to incident adult type 2 diabetes mellitus (T2DM).
RESEARCH DESIGN AND METHODS We used data from the International Childhood Cardiovascular Cohort (i3C) Consortium. Data included childhood (age 3-19 years) measurements obtained during the 1970s-1990s; a health questionnaire, including self-report of adult T2DM (occurrence age, medication use) obtained at mean age 40 years; and a medical diagnosis registry (Finland).
RESULTS The sample included 6,738 participants. Of these, 436 (6.5%) reported onset of T2DM between ages 20 and 59 (mean 40.8) years, and 86% of them reported use of a confirmed antidiabetic medication. BMI and glucose (age and sex standardized) were associated with incident T2DM after adjustment for cohort, country, sex, race, age, and calendar year of measurement. Increasing levels of childhood BMI and glucose were related to an incrementally increased risk of T2DM beginning at age 30 years, beginning at cut points <95th percentile for BMI and <100 mg/dL for glucose. Insulin was positively associated with adult T2DM after adjustment for BMI and glucose and added to T2DM discrimination.
CONCLUSIONS Childhood BMI and glucose are predictors of adult T2DM at levels previously considered to be within the normal range. These easy-to-apply measurements are appealing from a clinical perspective. Fasting insulin has the potential to be an additional predictor.
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