A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Mental awareness improved mild cognitive impairment and modulated gut microbiome
Tekijät: Khine Wei Wei Thwe, Voong Miao Lian, Ng Ted Kheng Siang, Feng Lei, Rane Grishma Avinash, Kumar Alan Prem, Kua Ee Heok, Mahendran Ratha, Mahendran Rathi, Lee Yuan-Kun
Kustantaja: IMPACT JOURNALS LLC
Julkaisuvuosi: 2020
Journal: Aging
Tietokannassa oleva lehden nimi: AGING-US
Lehden akronyymi: AGING-US
Vuosikerta: 12
Numero: 23
Aloitussivu: 24371
Lopetussivu: 24393
Sivujen määrä: 23
ISSN: 1945-4589
eISSN: 1945-4589
DOI: https://doi.org/10.18632/aging.202277
Rinnakkaistallenteen osoite: https://research.utu.fi/converis/portal/detail/Publication/51401138
There is ample scientific and clinical evidence of the effects of gut microbiota on the brain but no definitive evidence that the brain can affect changes in gut microbiota under the bi-directional gut-brain axis concept. As there is no pharmacotherapeutic intervention for the early stages of cognitive decline, research has focused on cognitive stimulation in reversing or slowing the impairment. Elderly patients diagnosed with mild cognitive impairment underwent a randomized-control trial of mindful awareness practice. Neuropsychological assessments, inflammatory markers, and gut microbiota profiles were tested. Here, we report that their cognitive impairment was improved and associated with changes in gut bacterial profile. A cognition-score-dependent-abundance was observed in Ruminococcus vs Recognition Trials (RT), Digit Span Backward (DSB), Semantic Fluency Span (SFS) and Memory Domain (MD); Coprococcus vs DSB, Color Trails Test 2 (CTT2) and Block Design (BD); Parabacteroides vs DSB and SFS; Fusobacterium vs DSB and CTT2; Enterobacteriaceae vs BD and SFS; Ruminococcaceae vs DSB; Phascolarctobacterium vs MD. The study showed for the first-time, alteration in the cognitive capacity leading to the corresponding changes in microbiota profiles. This strongly suggests that signals from the different segments of brain could dictate directly or indirectly the abundances of specific gut microbes.
Ladattava julkaisu This is an electronic reprint of the original article. |  |
