A1 Refereed original research article in a scientific journal
Cerebral Venous Thrombosis: Finnish Nationwide Trends
Authors: Ruuskanen Jori O, Kytö Ville, Posti Jussi P, Rautava Päivi, Sipilä Jussi OT
Publisher: LIPPINCOTT WILLIAMS & WILKINS
Publication year: 2021
Journal: Stroke
Journal name in source: STROKE
Journal acronym: STROKE
Volume: 52
Issue: 1
First page : 335
Last page: 338
Number of pages: 4
ISSN: 0039-2499
eISSN: 0039-2499
DOI: https://doi.org/10.1161/STROKEAHA.120.031026
Publication's open availability at the time of reporting: No Open Access
Publication channel's open availability : Delayed Open Access publication channel (the publications become open after an embargo period)
Web address : https://www.ahajournals.org/doi/10.1161/STROKEAHA.120.031026
Background and Purpose:Epidemiology of cerebral venous thrombosis (CVT) has been reported to be changing. Because long-term nationwide data are needed to confirm this, we studied CVT occurrence between 2005 and 2014 in Finland.
Methods:All acute CVT admissions were retrieved from a mandatory registry covering mainland Finland. Patients aged >= 18 years were included. One admission per patient was allowed.
Results:We identified 563 patients with CVT (56.5% women). Overall incidence was 1.32/100 000 (95% CI, 1.21-1.43) per year with a 5.0% annual increase. In people <55 years of age, incidence was 0.92/100 000 (0.76-1.10) for men and 1.65/100 000 (1.43-1.89) for women, whereas for those 55 years or older incidence was 1.61 (1.34-1.91) for men and 1.17 (0.96-1.41) for women. In-hospital mortality was 2.1% with no sex difference. One-year mortality was 7.9%. Long-term mortality was higher in men (adjusted hazard ratio, 1.61 [1.09-2.38]) and in older patients (1.95 [1.69-2.24]; per 10-year increment).
Conclusions:Overall incidence of CVT in Finland was similar to that reported in the Netherlands and in Australia. There was a 5.0% yearly increase in the rate of admissions while in-hospital mortality was low. Sex-specific incidence rates differed markedly between younger and older people. Long-term mortality increased with age and was higher in men.
