A2 Refereed review article in a scientific journal
Metabolic Signatures of the Exposome-Quantifying the Impact of Exposure to Environmental Chemicals on Human Health
Authors: Oresic M, McGlinchey A, Wheelock CE, Hyotylainen T
Publisher: MDPI
Publication year: 2020
Journal: Metabolites
Journal name in source: METABOLITES
Journal acronym: METABOLITES
Article number: ARTN 454
Volume: 10
Issue: 11
Number of pages: 31
eISSN: 2218-1989
DOI: https://doi.org/10.3390/metabo10110454
Web address : https://doi.org/10.3390/metabo10110454
Self-archived copy’s web address: https://research.utu.fi/converis/portal/detail/Publication/51291137
Human health and well-being are intricately linked to environmental quality. Environmental exposures can have lifelong consequences. In particular, exposures during the vulnerable fetal or early development period can affect structure, physiology and metabolism, causing potential adverse, often permanent, health effects at any point in life. External exposures, such as the "chemical exposome" (exposures to environmental chemicals), affect the host's metabolism and immune system, which, in turn, mediate the risk of various diseases. Linking such exposures to adverse outcomes, via intermediate phenotypes such as the metabolome, is one of the central themes of exposome research. Much progress has been made in this line of research, including addressing some key challenges such as analytical coverage of the exposome and metabolome, as well as the integration of heterogeneous, multi-omics data. There is strong evidence that chemical exposures have a marked impact on the metabolome, associating with specific disease risks. Herein, we review recent progress in the field of exposome research as related to human health as well as selected metabolic and autoimmune diseases, with specific emphasis on the impacts of chemical exposures on the host metabolome.
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