A1 Refereed original research article in a scientific journal
Interplay between gonadal hormones and postnatal overfeeding in defining sex-dependent differences in gut microbiota architecture
Authors: Santos-Marcos Jose A, Barroso Alexia, Rangel-Zuniga Oriol A, Perdices-Lopez Cecilia, Haro Carmen, Sanchez-Garrido Miguel A, Molina-Abril Helena, Ohlsson Claes, Perez-Martinez Pablo, Poutanen Matti, Lopez-Miranda Jose, Perez-Jimenez Francisco, Tena-Sempere Manuel, Camargo Antonio
Publisher: IMPACT JOURNALS LLC
Publication year: 2020
Journal: Aging
Journal name in source: AGING-US
Journal acronym: AGING-US
Volume: 12
Issue: 20
First page : 19979
Last page: 20000
Number of pages: 22
ISSN: 1945-4589
eISSN: 1945-4589
DOI: https://doi.org/10.18632/aging.104140
Self-archived copy’s web address: https://research.utu.fi/converis/portal/detail/Publication/51280130
Aging is associated with a decline in sex hormones, variable between sexes, that has an impact on many different body systems and might contribute to age-related disease progression. We aimed to characterize the sex differences in gut microbiota; and. to explore the impact of depletion of gonacial hormones, alone or combined with postnatal overfeeding, in rats. Many of the differences in the gut microbiota between sexes persisted after gonadectomy, but removal of gonadal hormones shaped several gut microbiota features towards a more deleterious profile, the effect being greater in females than in males, mainly when animals were concurrently overfed. Moreover, we identified several intestinal miRNAs as potential mediators of the impact of changes in gut microbiota on host organism physiology. Our study points out that gonadal hormones contribute to defining sex-dependent differences of gut microbiota, and discloses a potential role of gonadal hormones in shaping gut microbidta, OS consequence of the interaction between sex and nutrition. Our data suggest that the changes in gut microbion, observed in conditions of sex hormone decline, as those caused by ageing in men and menopause in women, might exert different effects on the host organism, which are putatively mediated by gut microbiota-intestinal miRNA cross-talk.
Downloadable publication This is an electronic reprint of the original article. |  |
