A1 Refereed original research article in a scientific journal
IL-6 and other biomarkers as predictors of severity in COVID-19
Authors: Broman N, Rantasärkkä K, Feuth T, Valtonen M, Waris M, Hohenthal U, Rintala E, Karlsson A, Marttila H, Peltola V, Vuorinen T, Oksi J
Publisher: Taylor & Francis
Publication year: 2021
Journal: Annals of Medicine
Journal name in source: Annals of medicine
Journal acronym: Ann Med
Volume: 53
Issue: 1
First page : 410
Last page: 412
Number of pages: 3
ISSN: 0785-3890
eISSN: 1365-2060
DOI: https://doi.org/10.1080/07853890.2020.1840621
Self-archived copy’s web address: https://research.utu.fi/converis/portal/detail/Publication/51268299
Objective
Cytokine release syndrome is suggested to be the most important mechanism triggering acute respiratory distress syndrome and end organ damage in COVID-19. The severity of disease may be measured by different biomarkers.
Methods
We studied markers of inflammation and coagulation as recorded in 29 patients on admission to the hospital in order to identify markers of severe COVID-19 and need of ICU.
Results
Patients who were eventually admitted to ICU displayed significantly higher serum levels of interleukin-6 (IL-6), C-reactive protein (CRP), and procalcitonin. No statistical differences were found between the groups in median levels of lymphocytes, D-dimer or ferritin.
Conclusions
IL-6 and CRP were the strongest predictors of severity in hospitalized patients with COVID-19.
Downloadable publication This is an electronic reprint of the original article. |  |
