Refereed journal article or data article (A1)

IL-6 and other biomarkers as predictors of severity in COVID-19




List of AuthorsBroman N, Rantasärkkä K, Feuth T, Valtonen M, Waris M, Hohenthal U, Rintala E, Karlsson A, Marttila H, Peltola V, Vuorinen T, Oksi J

PublisherTaylor & Francis

Publication year2021

JournalAnnals of Medicine

Journal name in sourceAnnals of medicine

Journal acronymAnn Med

Volume number53

Issue number1

Start page410

End page412

Number of pages3

ISSN0785-3890

eISSN1365-2060

DOIhttp://dx.doi.org/10.1080/07853890.2020.1840621

Self-archived copy’s web addresshttps://research.utu.fi/converis/portal/detail/Publication/51268299


Abstract

Objective

Cytokine release syndrome is suggested to be the most important mechanism triggering acute respiratory distress syndrome and end organ damage in COVID-19. The severity of disease may be measured by different biomarkers.

Methods

We studied markers of inflammation and coagulation as recorded in 29 patients on admission to the hospital in order to identify markers of severe COVID-19 and need of ICU.

Results

Patients who were eventually admitted to ICU displayed significantly higher serum levels of interleukin-6 (IL-6), C-reactive protein (CRP), and procalcitonin. No statistical differences were found between the groups in median levels of lymphocytes, D-dimer or ferritin.

Conclusions

IL-6 and CRP were the strongest predictors of severity in hospitalized patients with COVID-19.


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Last updated on 2022-07-04 at 18:19