Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1)

IL-6 and other biomarkers as predictors of severity in COVID-19

Julkaisun tekijät: Broman N, Rantasärkkä K, Feuth T, Valtonen M, Waris M, Hohenthal U, Rintala E, Karlsson A, Marttila H, Peltola V, Vuorinen T, Oksi J

Kustantaja: Taylor & Francis

Julkaisuvuosi: 2021

Journal: Annals of Medicine

Tietokannassa oleva lehden nimi: Annals of medicine

Lehden akronyymi: Ann Med

Volyymi: 53

Julkaisunumero: 1

Aloitussivu: 410

Lopetussivun numero: 412

Sivujen määrä: 3

ISSN: 0785-3890

eISSN: 1365-2060


Rinnakkaistallenteen osoite:



Cytokine release syndrome is suggested to be the most important mechanism triggering acute respiratory distress syndrome and end organ damage in COVID-19. The severity of disease may be measured by different biomarkers.


We studied markers of inflammation and coagulation as recorded in 29 patients on admission to the hospital in order to identify markers of severe COVID-19 and need of ICU.


Patients who were eventually admitted to ICU displayed significantly higher serum levels of interleukin-6 (IL-6), C-reactive protein (CRP), and procalcitonin. No statistical differences were found between the groups in median levels of lymphocytes, D-dimer or ferritin.


IL-6 and CRP were the strongest predictors of severity in hospitalized patients with COVID-19.

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Last updated on 2022-07-04 at 18:19