Eicosanoid Inflammatory Mediators Are Robustly Associated With Blood Pressure in the General Population
: Palmu J, Watrous JD, Mercader K, Havulinna AS, Lagerborg KA, Salosensaari A, Inouye M, Larson MG, Rong J, Vasan RS, Lahti L, Andres A, Cheng SS, Jousilahti P, Salomaa V, Jain M, Niiranen TJ, Niiranen TJ
Publisher: WILEY
: 2020
: Journal of the American Heart Association
: JOURNAL OF THE AMERICAN HEART ASSOCIATION
: J AM HEART ASSOC
: ARTN e017598
: 9
: 19
: 31
: 2047-9980
DOI: https://doi.org/10.1161/JAHA.120.017598
: https://research.utu.fi/converis/portal/detail/Publication/51211801
Background Epidemiological and animal studies have associated systemic inflammation with blood pressure (BP). However, the mechanistic factors linking inflammation and BP remain unknown. Fatty acid-derived eicosanoids serve as mediators of inflammation and have been suggested to regulate renal vascular tone, peripheral resistance, renin-angiotensin system, and endothelial function. We hypothesize that specific proinflammatory and anti-inflammatory eicosanoids are linked with BP. Methods and Results We studied a population sample of 8099 FINRISK 2002 participants randomly drawn from the Finnish population register (53% women; mean age, 48±13 years) and, for external validation, a sample of 2859 FHS (Framingham Heart Study) Offspring study participants (55% women; mean age, 66±9 years). Using nontargeted liquid chromatography-mass spectrometry, we profiled 545 distinct high-quality eicosanoids and related oxylipin mediators in plasma. Adjusting for conventional hypertension risk factors, we observed 187 (34%) metabolites that were significantly associated with systolic BP (P
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