A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Covid-19: Fat, Obesity, Inflammation, Ethnicity, and Sex Differences
Tekijät: Krams Indrikis A, Luoto Severi, Rantala Markus J, Joers Priit, Krama Tatjana
Kustantaja: MDPI
Julkaisuvuosi: 2020
Journal: Pathogens
Tietokannassa oleva lehden nimi: PATHOGENS
Lehden akronyymi: PATHOGENS
Artikkelin numero: ARTN 887
Vuosikerta: 9
Numero: 11
Sivujen määrä: 10
eISSN: 2076-0817
DOI: https://doi.org/10.3390/pathogens9110887
Rinnakkaistallenteen osoite: https://research.utu.fi/converis/portal/detail/Publication/51123392
Tiivistelmä
Although obesity is known to be a risk factor for COVID-19 severity, there is an urgent need to distinguish between different kinds of fat-visceral and subcutaneous fat-and their inflammation status in COVID-19. These different fat types have partially diverging biochemical roles in the human body, and they are differentially associated with SARS-CoV-2, which targets the angiotensin-converting enzyme 2 (ACE2) for cell entry. ACE2 is highly expressed in adipose tissue, especially in visceral fat, suggesting an important role for this tissue in determining COVID-19 disease severity. In this perspective article, we discuss group differences in the amount of visceral fat levels and the extent of inflammation in adipocytes of visceral fat tissue, which may, in part, drive population, cross-national, ethnic, and sex differences in COVID-19 disease. It is vital to steer the scientific community's attention to the effects of visceral fat in creating individual and population differences in COVID-19 severity. This can help researchers unravel the reasons for the reported population, ethnic, and sex differences in COVID-19 severity and mortality.
Although obesity is known to be a risk factor for COVID-19 severity, there is an urgent need to distinguish between different kinds of fat-visceral and subcutaneous fat-and their inflammation status in COVID-19. These different fat types have partially diverging biochemical roles in the human body, and they are differentially associated with SARS-CoV-2, which targets the angiotensin-converting enzyme 2 (ACE2) for cell entry. ACE2 is highly expressed in adipose tissue, especially in visceral fat, suggesting an important role for this tissue in determining COVID-19 disease severity. In this perspective article, we discuss group differences in the amount of visceral fat levels and the extent of inflammation in adipocytes of visceral fat tissue, which may, in part, drive population, cross-national, ethnic, and sex differences in COVID-19 disease. It is vital to steer the scientific community's attention to the effects of visceral fat in creating individual and population differences in COVID-19 severity. This can help researchers unravel the reasons for the reported population, ethnic, and sex differences in COVID-19 severity and mortality.
Ladattava julkaisu This is an electronic reprint of the original article. |  |
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