A1 Refereed original research article in a scientific journal
Non-Adherence to Statin Treatment in Older Patients with Peripheral Arterial Disease Depending on Persistence Status
Authors: Wawruch Martin, Wimmer Gejza, Murin Jan, Paduchova Martina, Petrova Miriam, Tesar Tomas, Matalova Petra, Havelkova Beata, Trnka Michal, Aarnio Emma
Publisher: MDPI
Publication year: 2020
Journal:: Biomedicines
Journal name in source: BIOMEDICINES
Journal acronym: BIOMEDICINES
Article number: ARTN 378
Volume: 8
Issue: 10
Number of pages: 12
eISSN: 2227-9059
DOI: https://doi.org/10.3390/biomedicines8100378
Self-archived copy’s web address: https://research.utu.fi/converis/portal/detail/Publication/51116309
The effectiveness of statins in secondary prevention of peripheral arterial disease (PAD) largely depends on patients' adherence to treatment. The aims of our study were: (a) to analyze non-adherence during the whole follow-up in persistent patients, and only during persistence for non-persistent patients; (b) to identify factors associated with non-adherence separately among persistent and non-persistent patients. A cohort of 8330 statin users aged >= 65 years, in whom PAD was newly diagnosed between January 2012-December 2012, included 5353 patients persistent with statin treatment, and 2977 subjects who became non-persistent during the 5-year follow-up. Non-adherence was defined using the proportion of days covered <80%. Patient- and statin-related characteristics associated with non-adherence were identified with binary logistic regression. A significantly higher proportion of non-adherent patients was found among non-persistent patients compared to persistent subjects (43.6% vs. 29.6%; p < 0.001). Associated with non-adherence in both persistent and non-persistent patients was high intensity statin treatment, while in non-persistent patients, it was employment and increasing number of medications. In patients with a poor adherence during their persistent period, an increased risk for discontinuation may be expected. However, there is also non-adherence among persistent patients. There are differences in factors associated with non-adherence depending on patients' persistence.
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