Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1)

The effect of smoking during pregnancy on severity and directionality of externalizing and internalizing symptoms: A genetically informed approach




Julkaisun tekijätEkblad M.O., Marceau K., Rolan E., Palmer R.H.C., Todorov A., Heath A.C., Knopik V.S.

KustantajaMDPI AG

Julkaisuvuosi2020

JournalInternational Journal of Environmental Research and Public Health

Tietokannassa oleva lehden nimiInternational Journal of Environmental Research and Public Health

Artikkelin numero7921

Volyymi17

Julkaisunumero21

Sivujen määrä12

eISSN1661-7827

DOIhttp://dx.doi.org/10.3390/ijerph17217921

Rinnakkaistallenteen osoitehttps://research.utu.fi/converis/portal/Publication/50939906


Tiivistelmä

The objective was to examine the association between maternal smoking during pregnancy (SDP) and (I) severity and (II) directionality of externalizing and internalizing symptoms in a sample of sibling pairs while rigorously controlling for familial confounds. The Missouri Mothers and Their Children Study is a family study (N = 173 families) with sibling pairs (aged 7 to 16 years) who are discordant for exposure to SDP. This sibling comparison study is designed to disentangle the effects of SDP from familial confounds. An SDP severity score was created for each child using a combination of SDP indicators (timing, duration, and amount). Principal component analysis of externalizing and internalizing behavior, assessed with the Child Behavior Checklist and Teacher Report Form, was used to create symptom severity and directionality scores. The variance in severity and directionality scores was primarily a function of differences between siblings (71% and 85%, respectively) rather than differences across families (29% and 15%, respectively). The severity score that combines externalizing and internalizing symptom severity was not associated with SDP. However, a significant within-family effect of SDP on symptom directionality (b = 0.07, p = 0.04) was observed in the sibling comparison model. The positive directionality score indicates that SDP is associated with differentiation of symptoms towards externalizing rather than internalizing symptoms after controlling for familial confounds with a sibling comparison model. This supports a potentially causal relationship between SDP and externalizing behavior.


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Last updated on 2021-24-06 at 12:10