A3 Vertaisarvioitu kirjan tai muun kokoomateoksen osa
Luteinizing Hormone Receptor: Structure, Signaling Mechanisms, and Physiological Functions in Leydig Cells
Tekijät: Rivero-Müller, Adolfo; Jonas, Kim Carol; Huhtaniemi, Ilpo
Toimittaja: Zirkin, Barry; Huhtaniemi, Ilpo; Lamb, Dolores J.; Papadopoulos, Vassilios
Painos: 1. edition
Kustantaja: Springer Science+Business Media
Julkaisuvuosi: 2025
Kokoomateoksen nimi: Leydig Cells: Formation Regulation and Function in Health and Disease
Aloitussivu: 227
Lopetussivu: 263
ISBN: 978-3-031-96375-9
eISBN: 978-3-031-96376-6
DOI: https://doi.org/10.1007/978-3-031-96376-6_8
Julkaisun avoimuus kirjaamishetkellä: Ei avoimesti saatavilla
Julkaisukanavan avoimuus : Ei avoin julkaisukanava
Verkko-osoite: https://link.springer.com/chapter/10.1007/978-3-031-96376-6_8
Pioneering studies suggested the existence of a specific receptor for LH (Lhr/LHCGR) in Leydig cells based on LH-induced testicular testosterone production. This was further supported by the specific high-affinity binding of radiolabeled hCG (a strong LH agonist) to Leydig cells. A plethora of information on the physiological function and regulation of the putative Lhr was subsequently obtained through ligand binding studies. The next milestone was the cloning of the Lhr gene, which opened up access to its molecular and structural biology, including detailed molecular mechanisms of its action. The purpose of this chapter is to briefly review the history of Lhr studies, concentrating on key findings on its role in the regulation of Leydig cell function in humans and experimental rodent models.
