A1 Refereed original research article in a scientific journal

Network controllability analysis of three multiple-myeloma patient genetic mutation datasets




AuthorsJose Angel Sanchez Martin, Ion Petre

Publication year2020

JournalFundamenta Informaticae

Volume175

Issue1-4

First page 281

Last page299

Number of pages19

ISSN0169-2968

eISSN1875-8681

DOIhttps://doi.org/10.3233/FI-2020-1957

Self-archived copy’s web addresshttps://research.utu.fi/converis/portal/detail/Publication/50631950


Abstract

Network controllability focuses on the concept of driving the dynamical system associated to a directed network of interactions from an arbitrary initial state to an arbitrary final state, through a well-chosen set of input functions applied in a minimal number of so-called input nodes. In earlier studies we and other groups demonstrated the potential of applying this concept in medicine. A directed network of interactions may be built around the main known drivers of the disease being studied, and then analysed to identify combinations of drug targets controlling survivability-essential genes in the network. This paper takes the next step and focuses on patient data. We demonstrate that comprehensive protein-protein interaction networks can be built around patient genetic data, and that network controllability can be used to identify possible personalised drug combinations. We discuss the algorithmic methods that can be used to construct and analyse these networks.


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