A1 Refereed original research article in a scientific journal
Network controllability analysis of three multiple-myeloma patient genetic mutation datasets
Authors: Jose Angel Sanchez Martin, Ion Petre
Publication year: 2020
Journal: Fundamenta Informaticae
Volume: 175
Issue: 1-4
First page : 281
Last page: 299
Number of pages: 19
ISSN: 0169-2968
eISSN: 1875-8681
DOI: https://doi.org/10.3233/FI-2020-1957
Self-archived copy’s web address: https://research.utu.fi/converis/portal/detail/Publication/50631950
Network controllability focuses on the concept of driving the dynamical system associated to a directed network of interactions from an arbitrary initial state to an arbitrary final state, through a well-chosen set of input functions applied in a minimal number of so-called input nodes. In earlier studies we and other groups demonstrated the potential of applying this concept in medicine. A directed network of interactions may be built around the main known drivers of the disease being studied, and then analysed to identify combinations of drug targets controlling survivability-essential genes in the network. This paper takes the next step and focuses on patient data. We demonstrate that comprehensive protein-protein interaction networks can be built around patient genetic data, and that network controllability can be used to identify possible personalised drug combinations. We discuss the algorithmic methods that can be used to construct and analyse these networks.
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