A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Incremental prognostic value of hybrid [15O]H2O positron emission tomography-computed tomography: combining myocardial blood flow, coronary stenosis severity, and high-risk plaque morphology
Tekijät: Roel S Driessen, Michiel J Bom, Pepijn A van Diemen, Stefan P Schumacher, Remi M Leonora, Henk Everaars, Albert C van Rossum, Pieter G Raijmakers, Peter M van de Ven, Cornelis C van Kuijk, Adriaan A Lammertsma, Juhani Knuuti, Amir Ahmadi, James K Min, Jonathon A Leipsic, Jagat Narula, Ibrahim Danad, Paul Knaapen
Kustantaja: Oxford University Press
Julkaisuvuosi: 2020
Journal: EHJ Cardiovascular Imaging / European Heart Journal - Cardiovascular Imaging
Tietokannassa oleva lehden nimi: European heart journal cardiovascular Imaging
Lehden akronyymi: Eur Heart J Cardiovasc Imaging
Vuosikerta: 21
Numero: 10
Aloitussivu: 1105
Lopetussivu: 1113
Sivujen määrä: 9
ISSN: 2047-2404
eISSN: 2047-2412
DOI: https://doi.org/10.1093/ehjci/jeaa192
Rinnakkaistallenteen osoite: https://research.utu.fi/converis/portal/detail/Publication/50617463
AimsThis study sought to determine the prognostic value of combined functional testing using positron emission tomography (PET) perfusion imaging and anatomical testing using coronary computed tomography angiography (CCTA)-derived stenosis severity and plaque morphology in patients with suspected coronary artery disease (CAD).Methods and resultsIn this retrospective study, 539 patients referred for hybrid [15O]H2O PET-CT imaging because of suspected CAD were investigated. PET was used to determine myocardial blood flow (MBF), whereas CCTA images were evaluated for obstructive stenoses and high-risk plaque (HRP) morphology. Patients were followed up for the occurrence of all-cause death and non-fatal myocardial infarction (MI). During a median follow-up of 6.8 (interquartile range 4.8–7.8) years, 42 (7.8%) patients experienced events, including 23 (4.3%) deaths, and 19 (3.5%) MIs. Annualized event rates for normal vs. abnormal results of PET MBF, CCTA-derived stenosis, and HRP morphology were 0.6 vs. 2.1%, 0.4 vs. 2.1%, and 0.8 vs. 2.8%, respectively (P < 0.001 for all). Cox regression analysis demonstrated prognostic values of PET perfusion imaging [hazard ratio (HR) 3.75 (1.84–7.63), P < 0.001], CCTA-derived stenosis [HR 5.61 (2.36–13.34), P < 0.001], and HRPs [HR 3.37 (1.83–6.18), P < 0.001] for the occurrence of death or MI. However, only stenosis severity [HR 3.01 (1.06–8.54), P = 0.039] and HRPs [HR 1.93 (1.00–3.71), P = 0.049] remained independently associated.ConclusionPET-derived MBF, CCTA-derived stenosis severity, and HRP morphology were univariably associated with death and MI, whereas only stenosis severity and HRP morphology provided independent prognostic value.
Ladattava julkaisu This is an electronic reprint of the original article. |  |
