A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Dietary intake of vitamins A, B, C, D and E and risk of islet autoimmunity and type 1 diabetes in genetically at-risk children: a prospective study from the DIPP birth cohort
Tekijät: Mattila, Markus; Haario, Peppi; Hakola, Leena; Takkinen, Hanna-Mari; Peltonen, Essi J.; Korhonen, Tuuli E.; Ahonen, Suvi; Ilonen, Jorma; Toppari, Jorma; Knip, Mikael; Veijola, Riitta; Niinistö, Sari; Virtanen, Suvi M.
Kustantaja: Springer Science and Business Media LLC
Julkaisuvuosi: 2025
Lehti: Diabetologia
ISSN: 0012-186X
eISSN: 1432-0428
DOI: https://doi.org/10.1007/s00125-025-06635-9
Julkaisun avoimuus kirjaamishetkellä: Avoimesti saatavilla
Julkaisukanavan avoimuus : Osittain avoin julkaisukanava
Verkko-osoite: https://doi.org/10.1007/s00125-025-06635-9
Rinnakkaistallenteen osoite: https://research.utu.fi/converis/portal/detail/Publication/506173815
Aims/hypothesis: In this prospective birth cohort study, we examined whether the dietary intake of A, B, C, D and E vitamins is associated with the risk of islet autoimmunity or type 1 diabetes in children who are genetically at risk for type 1 diabetes.
Methods: Data on vitamin intakes in the Finnish Type 1 Diabetes Prediction and Prevention (DIPP) cohort study were available for 5674 children born between September 1996 and September 2004 in Oulu University Hospital or Tampere University Hospital. Diet was assessed using 3-day food records at the age of 3 and 6 months, and annually from 1 to 6 years. The primary outcomes were: (1) islet autoimmunity defined as repeated positivity for islet cell autoantibodies and at least one out of three type 1 diabetes-related biochemical autoantibodies or a diagnosis of type 1 diabetes; and (2) a diagnosis of type 1 diabetes.
Results: During the 6-year follow-up, 247 children (4.4%) developed islet autoimmunity and 94 (1.7%) developed type 1 diabetes. When adjusted for total energy intake, sex, HLA genotype and family history of diabetes, the intakes of retinol (HR 0.91; 95% credible interval [CrI] 0.86, 0.97 per 10 µg/MJ increase in intake), vitamin C (HR 0.70; 95% CrI 0.54, 0.90 per 10 µg/MJ) and vitamin E (HR 0.93; 95% CrI 0.89, 0.97 per 0.1 mg/MJ) were associated with decreased risk of islet autoimmunity and also with the risk of type 1 diabetes (retinol: HR 0.83; 95% CrI 0.74, 0.96 per 10 µg/MJ; vitamin C: HR 0.45; 95% CrI 0.23, 0.84 per 10 µg/MJ; vitamin E: HR 0.89; 95% CrI 0.80, 0.99 per 0.1 mg/MJ). The associations remained statistically significant after multiple testing correction for the risk of islet autoimmunity but not for type 1 diabetes. The association between retinol intake and islet autoimmunity risk was not significant when the 3-month age point, during which the child is primarily breastfed, was excluded. We observed a weak inverse association for vitamin D and islet autoimmunity, and no associations for B vitamins.
Conclusions/interpretation: High intake of vitamin C and vitamin E was associated with a decreased risk of islet autoimmunity.
Ladattava julkaisu This is an electronic reprint of the original article. |  |
Julkaisussa olevat rahoitustiedot:
Open access funding provided by Tampere University (including Tampere University Hospital). The DIPP Nutrition Study was supported by the Research Council of Finland (grants 63672, 68292, 79685, 79686, 80846, 114666, 126813, 129492, 139391, 201988, 210632, 250114, 276475, 308066 and 339922); a European Foundation for the Study of Diabetes award supported by the EFSD/JDRF/Lilly; the Finnish Cultural Foundation; Competitive State Research Financing of the Expert Responsibility area of Tampere University Hospital (grants 9E082, 9F089, 9G087, 9H092, 9J147, 9K149, 9L042, 9L117, 9M036, 9M114, 9N086, 9P057, 9R055, 9S074, 9T072, 9U065, 9V072, 9X062, 9AA084, 9AB083, 9AC099, T63484 and T66994). The DIPP study overall has been supported by Competitive Research Funding of the Turku and Oulu University Hospitals; Breakthrough T1D (grants 4-1998-274, 4-1999-731, 4-2001-435, 1-SRA-2016-342-M-R, 1-SRA-2019-732-M-B and 3-SRA-2020-955-S-B); the Novo Nordisk Foundation; and the European Union Biomed 2 Program (BMH4-CT98-3314). The funders had no role in designing the study, or in the collection, analysis and interpretation of data, the writing of the report, or the decision to submit the article for publication.
