B1 Other refereed article (e.g., editorial, letter, comment) in a scientific journal

Allergic Rhinitis and Its Impact on Asthma (ARIA)-EAACI Guidelines—2024–2025 Revision: Part I—Guidelines on Intranasal Treatments



Authors: Sousa‐Pinto, Bernardo; Bousquet, Jean; Vieira, Rafael José; Schünemann, Holger J.; Zuberbier, Torsten; Bognanni, Antonio; Togias, Alkis; Samolinski, Boleslaw; Valiulis, Arunas; Williams, Sian; Bedbrook, Anna; Czarlewski, Wienczyslawa; Torres, Maria Jose; Shamji, Mohamed H.; Morais‐Almeida, Mário; Canonica, G. Walter; de las Vecillas, Leticia; Dykewicz, Mark S.; Jacomelli, Cristina; Klimek, Ludger; Leemann, Lucas; Lourenço, Olga; Palamarchuk, Yuliia; Papadopoulos, Nikolaos G.; Pereira, Ana Margarida; Savouré, Marine; Toppila‐Salmi, Sanna K.; Ventura, Maria Teresa; Yepes‐Nuñez, Juan José; Cruz, Alvaro A.; Ciprandi, Giorgio; Gemicioglu, Bilun; Giovannini, Mattia; Gradauskiene, Brigita; Jartti, Tuomas; Jeseňák, Miloš; Kuna, Piotr; Kvedariene, Violeta; Larenas‐Linnemann, Désirée E.; Latiff, Amir H. A.; Mohammad, Yousser; Ohta, Ken; Mahesh, Padukudru A.; Pali‐Schöll, Isabella; Pfaar, Oliver; Regateiro, Frederico S.; Roche, Nicolas; Taborda‐Barata, Luís; Ulrik, Charlotte Suppli; Rostan, Marylin Valentin; Viegi, Giovanni; Zhang, Luo; Haahtela, Tari; Cherrez‐Ojeda, Ivan; Ivancevich, Juan Carlos; Khaltaev, Nikolai; Yorgancioglu, Arzu; Abdullah, Baharudin; Al‐Ahmad, Mona; Al‐Nesf, Maryam Ali; Amaral, Rita; Asllani, Julijana; Bergmann, Karl‐C.; Bernstein, Jonathan A.; Blaiss, Michael S.; Braido, Fulvio; Camargos, Paulo; Carreiro‐Martins, Pedro; Casale, Thomas; Cecchi, Lorenzo; Fiocchi, Alessandro; Giuliano, Antonio F. M.; Christoff, George; Cirule, Ieva; de Sousa, Jaime Correia; Costa, Elisio M.; Del Giacco, Stefano; Devillier, Philippe; Dokic, Dejan; Hossny, Elham; Iinuma, Tomohisa; Irani, Carla; Ispayeva, Zhanat; Julge, Kaja; Kaidashev, Igor; Bennoor, Kazi S.; Kraxner, Helga; Kull, Inger; Kulus, Marek; Kupczyk, Maciej; Kurchenko, Andriy; La Grutta, Stefania; Miculinic, Neven; Tuyet, Lan Le Thi; Makris, Michael; Milenkovic, Branislava; Lee, Sang Min; Montefort, Stephen; Moreira, Andre; Mullol, Joaquim; Nadif, Rachel; Nakonechna, Alla; Neffen, Hugo E.; Niedoszytko, Marek; Nyembue, Dieudonné; O'Hehir, Robyn E.; Ogulur, Ismail; Okamoto, Yoshitaka; Olze, Heidi; Palomares, Oscar; Panzner, Petr; Patella, Vincenzo; Pawankar, Ruby; Pitsios, Constantinos; Popov, Todor A.; Puggioni, Francesca; Quirce, Santiago; Ramonaité, Agné; Recto, Marysia; Repka‐Ramirez, Maria Susana; Roberts, Graham; Robles‐Velasco, Karla; Rottem, Menachem; Salapatas, Marianella; Sastre, Joaquin; Scichilone, Nicola; Sisul, Juan‐Carlos; Solé, Dirceu; Soto‐Martinez, Manuel E.; Sova, Milan; Tantilipikorn, Pongsakorn; Todo‐Bom, Ana; Tsaryk, Vladyslav; Tsiligianni, Ioanna; Urrutia‐Pereira, Marilyn; Valovirta, Erkka; Vasankari, Tuula; Wallace, Dana; Wang, De Yun; Worm, Margitta; Yusuf, Osman M.; Zidarn, Mihaela; Gil‐Mata, Sara; Marques‐Cruz, Manuel; Mahboub, Bassam; Ansotegui, Ignacio J.; Romano, Antonino; Aberer, Werner; Artesani, Maria Cristina; Azzolini, Elena; Barreto, Bruno; Bartra, Joan; Becker, Sven; Beghe, Bianca; Boner, Attilio; Borowiack, Ewa; Bouchard, Jacques; Bourgoin‐Heck, Melisande; Brussino, Luisa; Buhl, Roland; Castillo‐Vizuete, José Antonio; Charpin, Denis; Chavannes, Niels H.; Chełmińska, Marta; Cheng, Lei; Chkhartishvili, Ekaterine; Cho, Seong H.; Chong‐Neto, Herberto Jose; Choudhury, Deepa; Chu, Derek K.; Cingi, Cemal; Compalati, Enrico; Albuquerque Costa, Raquel; Cunha, Olga Mariana; Cvetkovski, Biljana; Cardona‐Dahl, Victoria; D'Amato, Gennaro; Davies, Janet; Di Bona, Danilo; Gonzalez, Diaz Sandra N.; Dimou, Maria V.; Doulaptsi, Maria; Ferreira‐da‐Silva, Renato; Gawlik, Radoslaw; Calvo‐Gil, Mario; Goksel, Ozlem; Gómez, Maximiliano R.; Gotua, Maia; Grigoreas, Christos; Grisle, Ineta; Guzman, Maria Antonieta; House Tan, Rachel; Hyland, Michael; Ierodiakonou, Despo; Karavelia, Aspasia; Keith, Paul; Kisiel, Marta; Kosak, Tanja Soklic; Kosnik, Mitja; Koyuncu, Ilgim Vardaloglu; Kritikos, Vicky; Litynska, Justyna; Lombardi, Carlo; Louis, Gilles; Martini, Matteo; Meço, Cem; Mesonjesi, Eris; Mihaltan, Florin; Moniuszko, Marcin; Naclerio, Robert N.; Nadeau, Kari C.; Neisinger, Sophia; Ollert, Markus; Ordak, Michal; Paoletti, Giovanni; Park, Hae‐Sim; Parmelli, Elena; Perdomo‐Flores, Edgar Arturo; Pérez, José Miguel Fuentes; Pham‐Thi, Nhan; Prokopakis, Emmanuel; Ribeiro‐Vaz, Inês; Rolla, Giovanni; Romantowski, Jan; Rombaux, Philippe; Rouadi, Philip W.; Rukhadze, Maia; Ryan, Dermot; Sadowska, Ewelina; Sakurai, Daiju; Salameh, Laila; Sarquis, Faradiba Serpa; Serrano, Elie; Da Silva, Jane; Soyka, Michael; Specjalski, Krzysztof; Tomic‐Spiric, Vesna; Stevanovic, Katarina; Subramaniam, Abirami; Do Ceu Teixeira, Maria; Thomander, Tuuli; Vachova, Martina; van Hage, Marianne; Vichyanond, Pakit; Wagenmann, Martin; Ko, Fanny Wai San; Werminghaus, Pascal; Xepapadaki, Paraskevi Vicky; Xiang, Yi‐Kui; Yang, Qintai; Yeverino, Daniela Rivero; Zuberbier, Jaron; Fonseca, João A.

Publisher: Wiley

Publication year: 2025

Journal: Allergy

ISSN: 0105-4538

eISSN: 1398-9995

DOI: https://doi.org/10.1111/all.70131

Publication's open availability at the time of reporting: Open Access

Publication channel's open availability : Partially Open Access publication channel

Web address : https://doi.org/10.1111/all.70131

Self-archived copy’s web address: https://research.utu.fi/converis/portal/detail/Publication/505793773

Self-archived copy's licence: CC BY

Self-archived copy's version: Publisher`s PDF


Abstract
Background

Allergic rhinitis (AR) impacts quality of life, work and school productivity. Over the last years, an important body of evidence resulting from mHealth data has led to a better understanding of AR. Such advances have motivated an EAACI-endorsed update of the Allergic Rhinitis and its Impact on Asthma (ARIA) guidelines (ARIA 2024–2025). This manuscript presents the ARIA 2024–2025 recommendations for intranasal treatments, one of the mainstays for AR management.

Methods

The ARIA 2024–2025 guideline panel issued recommendations following the Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) evidence-to-decision framework. Several sources of evidence were used to inform panel judgments and recommendations, including systematic reviews, evaluation of mHealth and pharmacovigilance data, as well as a survey of experts on costs.

Results

Eleven guideline questions concerning intranasal treatments for AR were prioritized, leading to recommendations. Overall, these questions concern the choice between different classes of intranasal medications—most notably, intranasal corticosteroids (INCS), antihistamines (INAH), fixed combinations of INAH+INCS and decongestants—or between different individual medications within each class. Four questions had not been evaluated in previous ARIA guidelines, while for the other three there was a change in the strength or directionality of recommendations. Overall, recommendations point to the suggested use of INAH+INCS over INAH or INCS and INCS over INAH.

Conclusion

This ARIA 2024–2025 article supports patients, their caregivers, and healthcare professionals in choosing an intranasal treatment. However, decisions on AR treatment should consider the clinical variability of the disease, patients' values, and the affordability of medications.


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Funding information in the publication: 
The work of this study has been funded within the context of the Allergic Rhinitis and its Impact on Asthma (ARIA) group.


Last updated on 16/01/2026 10:53:32 AM