A4 Refereed article in a conference publication
Machine Learning meets Raman spectroscopy: a systematic review of literature in cancer diagnostics
Authors: Oancea, Bogdan; Necula, Marian; Milea, Eduard-Costin; Amărioarei, Alexandru; Petre, Ion; Păun, Mihaela-Marinela
Editors: Flearmoy, Jonathan
Conference name: International Conference on Knowledge-Based and Intelligent Information & Engineering Systems
Publication year: 2025
Journal: Procedia Computer Science
Book title : 29th International Conference on Knowledge-Based and Intelligent Information & Engineering Systems (KES 2025)
Volume: 270
First page : 2666
Last page: 2675
eISSN: 1877-0509
DOI: https://doi.org/10.1016/j.procs.2025.09.388
Publication's open availability at the time of reporting: Open Access
Publication channel's open availability : Open Access publication channel
Web address : https://doi.org/10.1016/j.procs.2025.09.388
Self-archived copy’s web address: https://research.utu.fi/converis/portal/detail/Publication/505714318
The integration of machine learning (ML) techniques with Raman spectroscopy has emerged as a promising strategy for advancing cancer diagnostics through label-free, high-resolution molecular analysis. This review aims to map and synthesize current research directions in this rapidly evolving field by conducting a structured review of existing review articles. Using a curated dataset of 70 reviews retrieved from Scopus and Web of Science, we applied Latent Dirichlet Allocation (LDA) topic modeling to uncover dominant thematic clusters across the literature. Our findings reveal five key research axes: (1) instrumentation and signal acquisition, (2) data preprocessing and spectral denoising, (3) classification models and algorithmic pipelines, (4) biomedical applications in oncology, and (5) emerging trends including deep learning and hybrid methods. This thematic structure highlights both the maturity and fragmentation of the current knowledge landscape. We also discuss the limitations of our approach, including database and article-type restrictions, and the use of LDA as a single modeling method. By identifying underexplored areas and recurring methodological challenges, this review contributes to a clearer understanding of the research gaps and future opportunities at the intersection of ML and Raman spectroscopy for cancer research.
Downloadable publication This is an electronic reprint of the original article. |
Funding information in the publication:
This work was supported in part by the MRID, project PNRR-I8 no 842027778, contract no 760096 and by the
Core Program within the National Research, Development and Innovation Plan 2022-2027, carried out with the
support of MRID, project no. 23020101(SIA-PRO), contract no 7N/2022.