A1 Refereed original research article in a scientific journal
A new verrucosane diterpenoid from the Vietnamese liverwort Plagiochila bantamensis
Authors: Le, Thi-Kim-Dung; Nguyen, Thi-Nhu-Quynh; Le, Thanh-Nguyen; Nguyen-Khanh-Trinh, Tram; Nguyen, Thi-Phuong; Nguyen, Thi-Hoai-Thu; Nguyen, Ngoc-Hong; Sichaem, Jirapast; Duong, Thuc-Huy
Publisher: Taylor & Francis
Publication year: 2025
Journal:Journal of Asian Natural Products Research
ISSN: 1028-6020
eISSN: 1477-2213
DOI: https://doi.org/10.1080/10286020.2025.2577286
Web address : https://doi.org/10.1080/10286020.2025.2577286
A new verrucosane-type diterpenoid, bantamenside (1), along with six known compounds (2–7), was isolated from the Vietnamese liverwort Plagiochila bantamensis. The structure of the new compound was determined using comprehensive spectroscopic methods, including 1D and 2D NMR techniques as well as high-resolution mass spectrometry. Furthermore, all isolated compounds were evaluated for their ability to inhibit nitric oxide (NO) production. Compounds 1–3 and 6–7 demonstrated notable NO inhibitory activity, with IC50 values ranging from 12.85 to 51.37 µM, outperforming or comparable to that of the positive control L-NMMA (IC50 41.30 ± 6.60 µM).
Funding information in the publication:
This research is funded by Ho Chi Minh city University of Education Foundation for Science and Technology under grant number CS.2024.19.51.
