A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Taxonomic expansion and reorganization of Flaviviridae
Tekijät: Simmonds, Peter; Butković, Anamarija; Grove, Joe; Mayne, Richard; Mifsud, Jonathon C. O.; Beer, Martin; Bukh, Jens; Drexler, J. Felix; Kapoor, Amit; Lohmann, Volker; Smith, Donald B.; Stapleton, Jack T.; Vasilakis, Nikos; Kuhn, Jens H.
Kustantaja: Springer Nature
Julkaisuvuosi: 2025
Lehti: Nature Microbiology
Vuosikerta: 10
Aloitussivu: 3026
Lopetussivu: 3037
eISSN: 2058-5276
DOI: https://doi.org/10.1038/s41564-025-02134-0
Julkaisun avoimuus kirjaamishetkellä: Ei avoimesti saatavilla
Julkaisukanavan avoimuus : Osittain avoin julkaisukanava
Verkko-osoite: https://doi.org/10.1038/s41564-025-02134-0
Flaviviridae is a family of non-segmented positive-sense RNA viruses that includes major pathogens such as hepatitis C virus, dengue viruses and yellow fever virus. Recent large-scale metagenomic surveys have identified many RNA viruses related to members of this family, such as orthoflaviviruses and pestiviruses. These viruses diverge by having different genome lengths and configurations, and host range. Here we performed an analysis of RNA-directed RNA polymerase (RdRP) hallmark gene sequences of flaviviruses and ‘flavi-like’ viruses. We uncovered four divergent clades and multiple lineages that are congruent with phylogenies of their helicase genes, protein profile hidden Markov model profiles, and evolutionary relationships based on predicted RdRP protein structures. These results support their classification into three families (Flaviviridae, Pestiviridae and Hepaciviridae) and 12 genera in the established order Amarillovirales, with groupings correlating with genome properties and host range. This taxonomy provides a framework for future evolutionary studies on this important viral family.
Julkaisussa olevat rahoitustiedot:
N.V. acknowledges partial support from the Centers for Research in Emerging Infectious Diseases (CREID) Coordinating Research on Emerging Arboviral Threats Encompassing the NEOtropics (CREATE-NEO) U01AI151807 grant by the National Institutes of Health (NIH). A.B. was supported by a postdoctoral fellowship from Foundation pour la Recherche Mèdicale (grant number SPF202110014092). J.G. was supported by a Wellcome Trust/Royal Society Sir Henry Dale Fellowship (107653/Z/15/Z) and MRC-University of Glasgow Centre for Virus Research core support from the Medical Research Council (MC_UU_00034/1). J.T.S. was supported by Veterans Administration Merit Review BX000207 and VA SEQCure Network grants.
