A1 Refereed original research article in a scientific journal

Immunophenotype based on inflammatory cells, PD-1/PD-L1 signalling pathway and M2 macrophages predicts survival in gastric cancer




AuthorsJunttila Anna, Helminen Olli, Väyrynen Juha P., Ahtiainen Maarit, Kenessey Istvan, Jalkanen Sirpa, Mecklin Jukka-Pekka, Kellokumpu Ilmo, Kuopio Teijo, Böhm Jan, Mrena Johanna

PublisherNATURE PUBLISHING GROUP

Publication year2020

JournalBritish Journal of Cancer

Journal name in sourceBRITISH JOURNAL OF CANCER

Journal acronymBRIT J CANCER

Volume123

Issue11

First page 1625

Last page1632

Number of pages8

ISSN0007-0920

eISSN1532-1827

DOIhttps://doi.org/10.1038/s41416-020-01053-7(external)

Self-archived copy’s web addresshttps://research.utu.fi/converis/portal/detail/Publication/50476259(external)


Abstract

Background

Immune response against cancer has prognostic impact but its role in gastric cancer is poorly known. The aim of the study was to assess the prognostic significance of immune cell score (CD3+, CD8+), tumour immune escape (PD-L1, PD-1) and immune tolerance (Clever-1). 

Methods
After exclusion of Epstein-Barr virus positive (n = 4) and microsatellite instable (n = 6) tumours, the study included 122 patients with GC undergoing D2 gastrectomy. CD3+ and CD8+ based ICS, PD-L1, PD-1 and Clever-1 expressions were evaluated. Differences in survival were examined using Cox regression adjusted for confounders. The primary outcome was 5-year survival. 

Results

The 5-year overall survival rate was 43.4%. High ICS was associated with improved overall survival (adjusted HR 0.48 (95% CI 0.26-0.87)) compared to low ICS. In the high ICS group, patients with PD-L1 expression (5-year survival 69.2 vs. 53.1%, p = 0.317), high PD-1 (5-year survival 70.6 vs. 55.3% p = 0.312) and high Clever-1 (5-year survival 72.0% vs. 45.5% (p = 0.070) had poor prognosis. 

Conclusions

High ICS was associated with improved survival. In the high ICS group, patients with high PD-L1, PD-1 and Clever-1 had poor prognosis highlighting the importance of immune escape and immune tolerance in GC.


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Last updated on 2024-26-11 at 18:37